PMID: 7234694Jun 1, 1981Paper

Exercise-induced angina provoked by aspirin administration in patients with variant angina

The American Journal of Cardiology
K MiwaC Kawai

Abstract

The effects of aspirin (4.0 g/day) given orally to eight patients with variant angina were observed. An exercise stress test performed in the morning was positive in two of seven patients during placebo administration, whereas a test performed in the afternoon at the same exercise work load resulted in negative findings. During aspirin administration, the afternoon exercise test repeatedly provoked anginal attacks associated with electrocardiographic changes (S-T segment elevation in five and S-T depression in two). Rate-pressure product at the end of the exercise test during aspirin administration was significantly lower than that during placebo administration (p less than 0.01). During aspirin administration, the frequency of angina increased markedly, and the attacks occurred not only during the night or early morning but also in the daytime in six of the eight patients. Our observations suggest that aspirin, in this large dose, reduces the capacity for exercise and provokes exercise-induced coronary arterial spasm in patients with variant angina.

References

May 17, 1979·The New England Journal of Medicine·S Moncada, J R Vane
Oct 1, 1979·The Journal of Clinical Endocrinology and Metabolism·H G GüllnerM S Kafka
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Citations

Jan 1, 1984·The American Journal of Cardiology·M McGregor, G L Crelinsten
Jun 27, 1983·The American Journal of Medicine·M McGregor
Sep 13, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·S SuedaT Uraoka
Jul 1, 1984·The American Journal of Cardiology·D D WatersP Theroux
Jan 1, 1985·Annals of the New York Academy of Sciences·F NumanoM Yajima
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·G A Lanza, A Maseri

Related Concepts

Angina Pectoris
Angina Pectoris, Variant
Zorprin
Electrocardiographic Recorders
Ergotrate
Cardiopulmonary Exercise Test
Placebos
Coronary Angiography

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