PMID: 15232779Jul 3, 2004Paper

Exercise-induced apoptosis in renal tubular cells of the rat

Folia morphologica
Marzena Podhorska-OkołówMaciej Zabel

Abstract

A number of studies have shown that acute physical exercise is associated with the induction of apoptosis not only in skeletal muscle but also in many distant organs. One of the pathogenic agents responsible for exercise-induced damage in many tissues is the generation of oxygen free radicals. The aim of the present study was to examine the influence of exercise-induced oxidative stress on the rat kidney. The analysis was performed on the kidneys of rats subjected to treadmill running until exhaustion. Our results demonstrated that acute exercise led to apoptotic damage of the renal distal tubular cells, although this was not a result of oxidative stress.

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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