PMID: 9424393Sep 1, 1996Paper

Exercise-induced asthma and the use of hypertonic saline aerosol as a bronchial challenge

Respirology : Official Journal of the Asian Pacific Society of Respirology
S D Anderson

Abstract

Exercise induced asthma is a common complaint and the prevalence appears to be increasing worldwide. Once confined to the research domain of university teaching hospitals, the study of EIA has extended into the school playground, defence force establishments and sports institutions. Standardized protocols have been developed to study EIA in the laboratory and in the field. A surrogate challenge using eucapnic or isocapnic hyperventilation with dry air is becoming popular because it has advantages over exercise, at least for adults. The stimulus that leads the airways to narrow is caused by the inhalation of dry air during hyperventilation and exercise, during which water is evaporated from the airways in order to condition the inspired air. The mechanism whereby the airways narrow is thought to be due to the dehydrating effects of water loss, particularly in relation to its potential to cause the airways to become hyperosmolar. Mast cell mediators such as histamine and the leucotrienes are probably involved in EIA because specific antagonists reduce severity. As a result of the osmotic theory of EIA, studies were carried out to determine whether subjects with EIA were sensitive to the effects of increasing airway osmolarity by ...Continue Reading

References

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Citations

Oct 12, 2000·Biochemical and Biophysical Research Communications·S M LoitschJ Bargon
Sep 4, 2015·International Forum of Allergy & Rhinology·Emily P Brigham, Natalie E West
Feb 24, 2006·The Korean Journal of Internal Medicine·Inseon S ChoiJang-Sik Moon
Mar 1, 2007·PLoS Medicine·Emmanuel O D Addo-YoboAdnan Custovic
Jul 31, 2013·Archivos de bronconeumología·Miguel Perpiñá TorderaUNKNOWN Spanish Society of Pulmonology and Thoracic Surgery (SEPAR)
Dec 7, 2018·Neurology India·Naghmeh Javanshir RezaeiSeyed Ahmad Naseri Alavi
Dec 10, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma· RatnawatiPaul S Thomas
Mar 18, 2000·The Journal of Biological Chemistry·J D HoffertL S King
Apr 9, 2020·Occupational and Environmental Medicine·Michael J AbramsonMalcolm Ross Sim
Aug 1, 2002·Drugs·Robert W Gotshall
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·P D JonesR L Henry

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