PMID: 6218749Feb 1, 1983

Exercise-induced cardiac dysfunction in sickle cell anemia. A radionuclide study

The American Journal of Cardiology
W CovitzR H DuRant

Abstract

Cardiac performance was studied by radionuclide angiography at rest and during exercise in 22 adolescents with sickle cell (SC) anemia and the results were compared with those in 12 control subjects. At rest, cardiac contractility was normal; cardiac output and end-diastolic volume were increased. At maximal exercise, heart rate, cardiac output response, and work capacity were reduced; the reduction was related to the degree of anemia. Left ventricular end-diastolic volume decreased with exercise most markedly in patients with ischemic exercise electrocardiograms. An abnormal ejection fraction response to exercise occurred in 4 patients; electrocardiographic signs of ischemia developed in all 4, and wall motion abnormalities in 2. Those patients who had electrocardiographic signs of ischemia had a significantly lower heart rate, ejection fraction, and cardiac output response to exercise, and a lower hematocrit level than subjects with normal results on exercise electrocardiography. The increase in cardiac output was not sufficient to maintain a normal level of exercise. The decrease in end-diastolic volume suggests that diastolic function was abnormal during exercise. Cardiac dysfunction was manifested by an abnormal ejection f...Continue Reading

References

Aug 1, 1978·The American Journal of Cardiology·J L GerryG M Hutchins
Nov 22, 1979·The New England Journal of Medicine·M B LeonA W Nienhuis
Mar 1, 1978·American Journal of Diseases of Children·W B StrongM Salehbhai
Jun 1, 1978·American Journal of Diseases of Children·M K ThaparM Salehbhai
Jun 1, 1978·British Heart Journal·A H ReesJ McFarlane
Jun 1, 1976·The American Journal of Medicine·J L GerryN J Fortuin
Mar 1, 1972·American Heart Journal·M A VaratN O Fowler
Apr 1, 1981·American Journal of Diseases of Children·B S AlpertT Hayashidera
Mar 1, 1964·The American Journal of Cardiology·N K UZSOY

Citations

May 7, 2002·American Journal of Respiratory and Critical Care Medicine·L A CallahanB Gutin
Jan 30, 2002·The Journal of Pediatrics·Maciej S BuchowskiKong Y Chen
Dec 10, 2003·Journal of Pediatric Hematology/oncology·Chatchawin AssanasenGeorge R Buchanan
Sep 5, 2002·American Journal of Hematology·Anjan S BatraPierre C Wong
Apr 6, 2018·Journal of Pediatric Hematology/oncology·Kelly A DoughertyVirginia A Stallings
Mar 29, 2019·Medicine and Science in Sports and Exercise·Laurent A MessonnierLéonard Féasson
Sep 27, 2001·Endothelium : Journal of Endothelial Cell Research·P BarbeauB Gutin

Related Concepts

Anemia, Sickle Cell
Cardiac Output
Coronary Heart Disease
Electrocardiographic Recorders
Cardiopulmonary Exercise Test
Cardiac Hypertrophy
Pulse Rate
Myocardial Contraction
Rest
Stroke Volume

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