Exercise-induced CD8 lymphocytosis: a phenomenon associated with large granular lymphocyte leukaemia

British Journal of Haematology
S P MulliganG A Young

Abstract

This report describes a patient with a large granular lymphocyte leukaemia (CD8 + lymphoproliferative disease) and severe neutropenia (less than 0.5 x 10(9)/l) in whom exercise resulted in a marked lymphocytosis, a phenomenon which has not previously been recorded. The lymphocyte count at rest was within normal limits (2.2 x 10(9)/l), then fell to the resting level within 15 min of cessation of exercise. The peripheral blood mononuclear cells showed the morphology of large granular lymphocytes (LGL) by light and electron microscopy both at rest (30%) and to a much greater extent during exercise (70%). Immunophenotyping of these lymphocytes during exercise demonstrated that the predominant cell was CD3+, CD8+, CD57+ (Leu7)/CD4-, CD16-, CD25-. In the resting state, despite a total lymphocyte count within the normal range, surface marker studies indicated an excess of cells with the CD8+/CD57 + T cell phenotype (26%; cf. normal range less than or equal to 10%). Functional assays revealed a minimal increase in natural killer (NK) activity during exercise. T cell receptor beta chain gene rearrangement was demonstrable in the peripheral blood at rest and during exercise. Although severe neutropenia was present, the growth of normal c...Continue Reading

References

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Citations

Oct 1, 1996·Leukemia & Lymphoma·T C GentileT P Loughran
Jan 1, 1994·Ultrastructural Pathology·E J WillsS Brammah
Jul 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·V K RehanJ M Bowman

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