PMID: 8937803Nov 1, 1996Paper

Exercise-induced changes in neuropeptide Y, noradrenaline and endothelin-1 levels in young people with type I diabetes

Clinical Physiology
G Ahlborg, J M Lundberg

Abstract

In search of early signs of autonomic and vascular dysfunction in diabetic subjects, six young men with type I diabetes and six healthy subjects were investigated regarding arterial levels of noradrenaline (NA), neuropeptide Y- (NPY) and endothelin-1-(ET-1) like immunoreactivity (Li) during and after 1 h of exercise at 70% of peak oxygen uptake. Basal NA, NPY-Li and ET-1-Li levels did not differ between groups. NA and NPY-Li rose during exercise in diabetic subjects to only 60% of the control values (P < 0.05, interaction group x time P < 0.001). Disappearance rates for NA and NPY-Li did not differ between groups. Plasma ET-1-Li did not differ between groups during exercise. Values returned to basal levels within 5 min in the diabetic but not in the control group. In conclusion, diabetic subjects show lower NPY-Li and NA levels than control subjects during exercise but similar disappearance rates after exercise, indicating lower releases. Furthermore, plasma ET-1 levels did not differ between groups during exercise.

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Citations

Jan 14, 2009·Expert Reviews in Molecular Medicine·Leena PradhanAristidis Veves
Jan 1, 2003·Journal of Neuroimmunology·Sammy BedouiStephan von Hörsten
Jan 15, 2010·The Journal of Surgical Research·Leena PradhanFrank W Logerfo
Oct 19, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jérémy ChéretChristelle Le Gall-Ianotto
Nov 24, 2012·Human & Experimental Toxicology·B R Goyal, A A Mehta
Aug 6, 2004·Endocrine Reviews·Zhi You FangThomas H Marwick
Oct 31, 2006·British Journal of Hospital Medicine·Ian Gallen
Aug 4, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Bryan WilliamsPatrick Brunel
Jun 16, 2012·Journal of Applied Physiology·Silvana RobertoAntonio Crisafulli
Apr 25, 2020·International Journal of Molecular Sciences·Antonio CrisafulliClaudia Penna
Dec 4, 2019·Autonomic Neuroscience : Basic & Clinical·Georgios Theocharidis, Aristidis Veves

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