Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Spinal Cord Injury

Journal of Neurotrauma
Soha J ChhayaMegan Ryan Detloff

Abstract

Spinal cord injury (SCI) induces neuropathic pain that is refractory to treatment. Central and peripheral immune responses to SCI play critical roles in pain development. Although immune responses in the dorsal horn have been implicated in SCI-pain, immune mechanisms in the periphery, especially in the dorsal root ganglia (DRG), where nociceptor cell bodies reside, have not been well studied. Exercise is an immunomodulator, and we showed previously that early exercise after SCI reduces pain development. However, the mechanisms of exercise-mediated pain reduction are not understood. Therefore, we examined the 1) underlying immune differences in the spinal cord and DRG between rats with and without pain and 2) immunomodulatory effects of exercise in pain reduction. Rats were subjected to a unilateral contusion at C5 and tested for pain development using von Frey and mechanical conflict-avoidance paradigms. A subgroup of rats was exercised on forced running wheels starting at 5 days post-injury for 4 weeks. We observed greater microglial activation in the C7-C8 dorsal horn of rats with SCI-induced pain compared to rats with normal sensation, and early exercise reduced this activation independently of pain behavior. Further, abnorm...Continue Reading

References

Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W J Dixon
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Jul 14, 2000·Physiological Reviews·B K Pedersen, L Hoffman-Goetz
Aug 23, 2000·British Journal of Sports Medicine·B K Pedersen, A D Toft
Jul 11, 2001·Journal of Neuropathology and Experimental Neurology·P G Popovich, W F Hickey
Jul 31, 2001·Trends in Neurosciences·L R WatkinsS F Maier
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
Apr 5, 2003·Journal of Neurotrauma·Stephen W ScheffJames E Lumpp
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Catherine AbbadieMichael J Forrest
Dec 25, 2003·Muscle & Nerve·Esther E Dupont-VersteegdenCharlotte A Peterson
Apr 8, 2004·Brain : a Journal of Neurology·Karen J HutchinsonD Michele Basso
May 5, 2005·Experimental Neurology·Zhe YingFernando Gómez-Pinilla
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fletcher A WhiteRichard J Miller
Oct 15, 2005·Nature Reviews. Drug Discovery·Fletcher A WhiteRichard J Miller
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan C Hains, Stephen G Waxman
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peng ZhaoBryan C Hains
Jul 17, 2007·Biochemical and Biophysical Research Communications·Hiroshi KanamoriHidenori Arai
Sep 25, 2007·The Journal of Pain : Official Journal of the American Pain Society·Karen E KuphalBradley K Taylor
Oct 30, 2007·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
May 16, 2008·Nature·Geoffrey C GurtnerMichael T Longaker
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander M BinshtokTarek A Samad
Jan 17, 2009·Brain Research Reviews·Catherine AbbadieFletcher A White
Mar 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John C GenselPhillip G Popovich
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong-Jing GaoRu-Rong Ji
Jun 6, 2009·Journal of Neurotrauma·Harra R Sandrow-FeinbergJohn D Houle
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristina A KigerlPhillip G Popovich
Feb 2, 2010·Pharmacology & Therapeutics·Yong-Jing Gao, Ru-Rong Ji
Jul 21, 2010·Experimental Neurology·Megan Ryan DetloffD Michele Basso
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Supinder S BediEdgar T Walters
Nov 12, 2010·Nature·Richard M Ransohoff, Astrid E Cardona
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juliette Van SteenwinckelStéphane Mélik Parsadaniantz
Jun 16, 2011·Nature Reviews. Neuroscience·Samuel David, Antje Kroner
Jul 12, 2011·Brain Research·Cristina Fabiola Kim, Gila Moalem-Taylor
Aug 2, 2011·Molecular Brain·Min ZhuoLong-Jun Wu

❮ Previous
Next ❯

Citations

Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Edgar T Walters
Aug 15, 2020·Frontiers in Cellular Neuroscience·Micaela L O'Reilly, Veronica J Tom
Jan 12, 2021·Neurobiology of Pain·Courtney A BannermanNader Ghasemlou
Dec 10, 2020·European Journal of Pain : EJP·Gary H BlumenthalKaren A Moxon
Jan 16, 2021·Cells·Ganchimeg DavaaJung Keun Hyun
Dec 18, 2019·Experimental Neurology·Ona BloomAnn M Spungen
Jan 26, 2021·Pain Reports·Joseph B Lesnak, Kathleen A Sluka
Mar 23, 2021·Sports Medicine - Open·Brianna N Leitzelar, Kelli F Koltyn
May 5, 2021·Neuroscience·Eduarda Gomes FerrariniRafael Cypriano Dutra
Jun 3, 2021·International Journal of Molecular Sciences·Jadwiga N BilchakMarie-Pascale Côté

❮ Previous
Next ❯

Software Mentioned

ImageJ
SigmaPlot

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Topics in Health Care Financing
M J Haley
Progress in Neurological Surgery
Liong Liem
Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Michael F EspositoTimothy R Deer
Journal of the American College of Surgeons
William G Plested
© 2022 Meta ULC. All rights reserved