PMID: 11900969Mar 20, 2002Paper

Exercise-induced hyperkalemia in hypothyroid dogs

Domestic Animal Endocrinology
I A SchaafsmaM E Everts

Abstract

We investigated the effect of hypothyroidism in dogs on (1) the Na+-, K+ -ATPase concentration in skeletal muscle, and (2) potassium (K+) homeostasis at rest and during exercise. Prior to and 1 year after induction of hypothyroidism by surgery and subsequent radiothyroidectomy, the Na+-, K+ -ATPase concentrations were quantified in biopsies of sternothyroid muscles of seven Beagle dogs by measuring [3H]ouabain binding capacity. In addition, plasma K+ concentrations were measured at rest and after treadmill exercise in six hypothyroid and seven euthyroid Beagle dogs. During hypothyroidism, the mean Na+ -, K+ -ATPase concentration in muscle biopsies was 41% lower than during euthyroidism. The mean resting plasma K+ value of the hypothyroid dogs was significantly (14%) higher than that of the euthyroid dogs. In the hypothyroid dogs, plasma K+ concentration increased significantly during exercise, whereas there was no rise in the euthyroid dogs. The rise in plasma K+ concentration could not be ascribed to muscle damage, as plasma creatine kinase concentrations remained within reference range. Also renal K+ retention was an unlikely explanation, as plasma aldosterone concentration and plasma renin activity rather increased than decr...Continue Reading

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Citations

May 5, 2011·New Zealand Veterinary Journal·C T Mooney
Apr 17, 2008·Journal of the American Veterinary Medical Association·Davis M SeeligPaul R Avery
Aug 21, 2013·Seminars in Nephrology·Chih-Jen ChengChou-Long Huang
Oct 6, 2005·Domestic Animal Endocrinology·B A SchotanusM E Everts
Feb 11, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ichiro HorieAtsushi Kawakami
Oct 28, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tetsuro NiriAtsushi Kawakami
Sep 25, 2003·Physiological Reviews·Torben Clausen

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