Exercise-induced increases in NT-proBNP are not related to the exercise-induced immune response

British Journal of Sports Medicine
Jürgen ScharhagWilfried Kindermann

Abstract

To investigate if the exercise-induced immune response contributes to the exercise-induced increase in brain natriuretic peptide (BNP) in healthy athletes. This has previously been speculated, as elevated concentrations of BNP or N-terminal pro brain natriuretic peptide (NT-proBNP) in cardiovascular patients were found to be related to immune reactions and elevations in inflammatory cytokines such as interleukin 6 (IL-6). Stored serum samples were analysed for NT-proBNP concentrations of 14 healthy endurance athletes (mean age: 25 (SD 5) years; VO(2peak) 67 (SD 6) ml/min/kg), who had been examined previously for exercise-induced immune reactions and their dependence on carbohydrate supplementation (6 or 12% carbohydrate vs placebo beverages) after three bouts of 4 h cycling at a given workload of 70% of the individual anaerobic threshold. Venous blood samples were taken before, immediately after, and 1 h and 1 day after exercise. Leucocyte subpopulations were determined immediately after blood sampling by flow cytometry. Serum samples for posterior analysis of C-reactive protein (CRP), IL-6, cortisol and NT-proBNP were stored at -80 degrees C. The exercise-induced increases in NT-proBNP (p<0.001) were not related to the exercis...Continue Reading

Citations

Mar 12, 2011·European Journal of Applied Physiology·David WoodsAdrian Mellor
Jun 11, 2011·European Journal of Applied Physiology·Bo FernhallDenise Smith
Jan 24, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ye TianChuanye Huang
Feb 19, 2013·International Journal of Pediatric Otorhinolaryngology·Bulent OranDerya Arslan
Oct 21, 2014·High Altitude Medicine & Biology·Adrian MellorDavid Woods
Apr 7, 2011·Journal of the Royal Army Medical Corps·D R WoodsN de Alwis
Mar 31, 2011·Medicine and Science in Sports and Exercise·Johannes ScherrMartin Halle

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