Exercise-induced oxidative stress and muscle stress protein responses in trotters

European Journal of Applied Physiology
Susanna KinnunenMustafa Atalay

Abstract

Acute exercise induces oxidative stress and heat shock protein (HSP) expression. Information on the protection of stress proteins against oxidant insult and muscle damage during moderate exercise is scanty. We aimed to show how a single bout of moderate exercise affects the markers of oxidative stress and heat shock factor-1 (HSF1; the transcriptional regulator of HSP synthesis), and HSP70, HSP90 and glucose-regulated protein (GRP75) expression in horses. Eight clinically normal and regularly trained standardbred trotters were treadmill-exercised for 45 min at moderate intensity. Blood samples were collected prior to and immediately after exercise and at 4 and 24 h of recovery. Muscle biopsy samples from the middle gluteal muscle were taken before exercise and after 4 h of recovery. Acute exercise did not activate HSF1 or induce expression of HSP70, HSP90 or GRP75 in skeletal muscle. One bout of acute exercise increased protein oxidation, which was measured by protein carbonyls in plasma and muscle, but it did not effect 4-hydroxynonenal protein adducts, which are markers of lipid peroxidation. Furthermore, mild muscle damage was observed 4 h after exercise. Our results showed that horses are susceptible to oxidative stress. On...Continue Reading

References

Nov 1, 1992·Journal of Applied Physiology·M B ReidM S West
Apr 1, 1983·Australian Veterinary Journal·R J RoseW Chan
Oct 27, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·E ChiaradiaA Gaiti
Aug 19, 2000·International Journal of Sports Medicine·Y LiuJ M Steinacker
Jan 9, 2001·Frontiers in Bioscience : a Journal and Virtual Library·Y Liu, J M Steinacker
Mar 17, 2001·Medicine and Science in Sports and Exercise·S K PowersH A Demirel
Jan 25, 2002·Annals of the New York Academy of Sciences·E R Stadtman
May 15, 2002·Brain Research. Molecular Brain Research·K KaarnirantaM J Lammi
Oct 31, 2002·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·N K J OksalaE Alhava
Oct 31, 2002·Equine Veterinary Journal. Supplement·A R PösöE Pirilä

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Citations

Dec 16, 2004·Journal of Physiological Anthropology and Applied Human Science·Kee-Bum KimDong-Jun Lee
Jun 4, 2014·The Veterinary Journal·B A MurphyJ A Elliott
Sep 2, 2005·European Journal of Applied Physiology·Susanna KinnunenMustafa Atalay
Jul 21, 2009·Free Radical Biology & Medicine·Aristidis S VeskoukisDimitrios Kouretas
Sep 28, 2007·The Veterinary Journal·Nathalie KirschvinkPierre Lekeux
Aug 18, 2006·The Veterinary Journal·Jens Lykkesfeldt, Ove Svendsen
Jun 27, 2006·Journal of Diabetes and Its Complications·Niku K J OksalaMustafa Atalay
May 18, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mustafa GulOsmo Hänninen
Jan 1, 2011·Journal of Equine Science·Yoshio MinamiHirofumi Miyata
Sep 18, 2010·Journal of Applied Physiology·Ann-Marie MartinBarbara A Murphy
Apr 30, 2019·BioMed Research International·Jolanta BujokTomasz Walski
Aug 29, 2007·Analytica Chimica Acta·Rodrigo PossariLauro Tatsuo Kubota

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