Exercise-induced oxidative stress influences the motor control during maximal incremental cycling exercise in healthy humans

Respiratory Physiology & Neurobiology
Gilles GravierYves Jammes


We hypothesized that the changes in blood oxidant/antioxidant status during incremental maximal cycling exercise could affect the motor drive to leg muscles. Indeed, the oxygen free radicals activate the metabosensitive muscle afferents which are suspected to elicit an adaptive motor response delaying fatigue. Fifteen healthy subjects performed an incremental cycling exercise reaching the maximal oxygen uptake (VO2) during which venous blood was repeatedly sampled to measure a marker of lipid peroxidation (TBARS), an antioxidant (reduced ascorbic acid, RAA), and the ischaemia-modified albumin (IMA). The surface EMG of rectus femoris was recorded and the median frequency (MF) of power spectrum was computed. Our main results are: 1) TBARS increased in 7/15 subjects, RAA decreased in 7/15 and IMA increased in 13/15 at VO2max; 4) the MF decrease was correlated to maximal end-exercise IMA increase and RAA decrease. During maximal cycling exercise, the adaptive motor response to cycling closely depends on the magnitude of exercise-induced oxidative stress.


May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Oct 1, 1986·The Journal of Physiology·B R Bigland-RitchieO C Lippold
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·E Marcos, J Ribas
Feb 1, 1993·Medicine and Science in Sports and Exercise·H M Alessio
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·F MaltaisP LeBlanc
Jan 1, 1997·European Journal of Applied Physiology and Occupational Physiology·R JansenA L Hof
Feb 2, 1999·The Journal of Physiology·K OstrowskiB K Pedersen
Jan 24, 2002·Experimental Physiology·Barry W ScheuermannThomas J Barstow
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Adam SteensbergBente Klarlund Pedersen
Jan 2, 2003·The Journal of Physiology·Jørn W HelgeErik A Richter
Aug 14, 2003·Clinical Physiology and Functional Imaging·François HugYves Jammes
Aug 20, 2003·Biochemistry·Sebastián CarballalBeatriz Alvarez
May 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Damian M BaileyRussell S Richardson
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A RobergsDaryl Parker
Nov 4, 2004·Respiratory Physiology & Neurobiology·Yves JammesStéphane Delliaux
Feb 14, 2006·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Louis CarregaRegis Guieu
Oct 30, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·David Bar-OrC Gerald Curtis
Aug 25, 2009·Pflügers Archiv : European journal of physiology·Stephane DelliauxYves Jammes
Oct 9, 2009·European Journal of Applied Physiology·Clayton L CamicRichard J Schmidt
Oct 12, 2010·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Matthew S TenanKyle Leppert
Jun 18, 2011·Biochemical and Biophysical Research Communications·Perrine PellegrinoOliver Schäf
Feb 22, 2012·Clinical Biochemistry·Kassiano AlbarelloRafael Noal Moresco
Mar 15, 2012·Theoretical Biology & Medical Modelling·John F Moxnes, Øyvind Sandbakk

❮ Previous
Next ❯


Mar 20, 2015·Canadian Journal of Physiology and Pharmacology·Fabrice JouliaRégis Guieu

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.