Exercise-induced quadriceps muscle fatigue in men and women: effects of arterial oxygen content and respiratory muscle work

The Journal of Physiology
Paolo B DominelliA William Sheel

Abstract

High work of breathing and exercise-induced arterial hypoxaemia (EIAH) can decrease O2 delivery and exacerbate exercise-induced quadriceps fatigue in healthy men. Women have a higher work of breathing during exercise, dedicate a greater fraction of whole-body V̇O2 towards their respiratory muscles and develop EIAH. Despite a greater reduction in men's work of breathing, the attenuation of quadriceps fatigue was similar between the sexes. The degree of EIAH was similar between sexes, and regardless of sex, those who developed the greatest hypoxaemia during exercise demonstrated the most attenuation of quadriceps fatigue. Based on our previous finding that women have a greater relative oxygen cost of breathing, women appear to be especially susceptible to work of breathing-related changes in quadriceps muscle fatigue. Reducing the work of breathing or eliminating exercise-induced arterial hypoxaemia (EIAH) during exercise decreases the severity of quadriceps fatigue in men. Women have a greater work of breathing during exercise, dedicate a greater fraction of whole-body V̇O2 towards their respiratory muscles, and demonstrate EIAH, suggesting women may be especially susceptible to quadriceps fatigue. Healthy subjects (8 male, 8 fe...Continue Reading

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Citations

Jan 24, 2018·Journal of Applied Physiology·Bruno ArchizaA William Sheel
Aug 26, 2017·Experimental Physiology·Paolo B DominelliA William Sheel
May 25, 2018·Journal of Applied Physiology·Paolo B DominelliGlen E Foster
Jul 20, 2018·Journal of Applied Physiology·Paolo B DominelliMichael J Joyner
Jul 4, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Catherine F NotariusJ Kevin Shoemaker
Oct 12, 2018·Journal of Applied Physiology·Joseph F WelchA William Sheel
Nov 10, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Paolo B Dominelli, A William Sheel
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Jul 26, 2019·Medicine and Science in Sports and Exercise·Paul W MarshallRoger M Enoka
Mar 1, 2019·Exercise and Sport Sciences Reviews·Paolo B DominelliA William Sheel
Sep 24, 2020·The Journal of Physiology·Paul AnsdellStuart Goodall
Jun 4, 2020·BMC Neuroscience·Oliver Seidel-Marzi, Patrick Ragert
Jul 23, 2020·Medicine and Science in Sports and Exercise·Keren ConstantiniRobert F Chapman
Mar 15, 2021·Mayo Clinic Proceedings·Paolo B DominelliMichael J Joyner
Apr 28, 2021·European Journal of Applied Physiology·Bruno ArchizaA William Sheel
Aug 28, 2021·International Journal of Environmental Research and Public Health·Felipe Contreras-BriceñoGinés Viscor

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