PMID: 8964754Mar 1, 1996Paper

Exercise-induced stimulation of murine macrophage phagocytosis may be mediated by thyroxine

Journal of Applied Physiology
M A FornerE Ortega

Abstract

The present study was designed to test the hypothesis that changes in plasma concentrations of hormones may be responsible for the exercise-induced macrophage phagocytic stimulation. The effect of 30-min incubation of macrophages with plasma from mice previously exposed to swimming until exhaustion (with or without previous training) was studied, and the results showed a similar stimulation of the phagocytic capacity (attachment and ingestion) of these cells to that found in previous studies after exercise. Also, changes in plasma concentration of both thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3) after exercise were measured, and their effect on phagocytic capacity after in vitro incubation with peritoneal macrophages was investigated. Results indicated that, after exercise, plasma concentrations of T3 and T4 increased. Incubation of peritoneal macrophages for 30 min with a concentration of T3 similar to that observed in the plasma immediately after exercise (1.5 ng/ml) induced no modifications in the phagocytic capacity. However, a physiological concentration of T4 after exercise (75 ng/ml) stimulated the phagocytic capacity of peritoneal macrophages. In addition, a 10,000-fold greater concentration of these thyroid horm...Continue Reading

Citations

Sep 29, 2004·Acta Physiologica Scandinavica·H YanoS Kira
Jul 13, 2011·Thyroid : Official Journal of the American Thyroid Association·Paolo De VitoPaul J Davis
Aug 18, 2001·Journal of Applied Physiology·E Ortega RincónH Lötzerich
Mar 9, 2017·International Reviews of Immunology·María Cecilia OpazoClaudia A Riedel
Feb 2, 1999·Medicine and Science in Sports and Exercise·J A WoodsD C Nieman
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S H SuC J Jen
Jan 26, 2018·Pharmacological Reports : PR·Elżbieta GałeckaJanusz Szemraj
Apr 13, 2018·Endocrinology·Anne H van der SpekAnita Boelen
Apr 30, 2019·Endocrine Reviews·Antonio C BiancoBarbara M L C Bocco
Nov 18, 2016·The Journal of Endocrinology·Anne H van der SpekAnita Boelen
Jun 20, 2019·Frontiers in Endocrinology·María Del Mar Montesinos, Claudia Pellizas
Jan 18, 2021·Immunology·Martin JaegerRomana T Netea-Maier
Dec 5, 2020·Endocrinology·Anne H van der SpekAnita Boelen

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