Exercise intensity-dependent immunomodulatory effects on encephalomyelitis

Annals of Clinical and Translational Neurology
Nina FainsteinOfira Einstein

Abstract

Exercise training (ET) has beneficial effects on multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). However, the intensity-dependent effects of ET on the systemic immune system in EAE remain undefined. (1) To compare the systemic immune modulatory effects of moderate versus high-intensity ET protocols in protecting against development of EAE; (2) To investigate whether ET affects autoimmunity selectively, or causes general immunosuppression. Healthy mice performed moderate or high-intensity treadmill running programs. Proteolipid protein (PLP)-induced transfer EAE was utilized to examine ET effects specifically on the systemic immune system. Lymph node (LN)-T cells from trained versus sedentary donor mice were transferred to naïve recipients and EAE severity was assessed, by clinical assessment and histopathological analysis. LN-T cells derived from donor trained versus sedentary PLP-immunized mice were analyzed in vitro for proliferation assays by flow cytometry analysis and cytokine and chemokine receptor gene expression using real-time PCR. T cell-dependent immune responses of trained versus sedentary mice to the nonautoantigen ovalbumin and susceptibility to Escherichia coli-induced acu...Continue Reading

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Citations

Apr 19, 2020·Current Opinion in Neurology·Diego CentonzePeter Feys
Oct 2, 2019·Frontiers in Immunology·Antonietta GentileGeorgia Mandolesi
Sep 25, 2020·Journal of Clinical Medicine·Remsha AfzalClaire E McCoy
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Dec 8, 2020·Annals of Clinical and Translational Neurology·Yehuda GoldbergOfira Einstein
Apr 2, 2021·Scientific Reports·Brian Mark LozinskiAntoine Dufour

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Methods Mentioned

BETA
flow cytometry
PCR

Software Mentioned

CXP
Image J

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