Exercise intervention for post-treatment colorectal cancer survivors: a systematic review and meta-analysis.

Journal of Cancer Survivorship : Research and Practice
Ruitong GaoLirong Guo

Abstract

This study aimed to explore the effects of exercise on post-treatment colorectal cancer survivors through a systematic review and meta-analysis as the current information is limited and controversial. We searched PubMed, Web of Science, Embase, and Cochrane Library databases for randomized controlled trials that focused on exercise intervention for adult colorectal cancer survivors who had completed primary cancer treatment. We extracted and pooled information regarding psychosocial outcomes, physical functions, body composition, metabolic growth factors, and/or tumor-related biomarkers. All data were assessed by two independent reviewers. The risk of bias was assessed using the Cochrane Collaboration's tool. A total of 20 studies, which presented data from 1223 post-treatment colorectal cancer survivors, matched the inclusion criteria. Compared with usual care or usual lifestyle, exercise intervention increased VO2peak (n = 107, SMD = 0.72, 95% CI = 0.32 to 1.11, I2 = 41%, P = 0.0004), reduced fasting insulin levels and insulin resistance (n = 150, SMD = - 0.55, 95% CI = - 0.88 to - 0.23, I2 = 0%, P = 0.0009; SMD = - 0.62, 95% CI = - 0.95 to - 0.29, I2 = 0%, P = 0.0002), and decreased levels of sICAM-1. Moderate-intensity exer...Continue Reading

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Citations

Sep 26, 2020·The International Journal of Behavioral Nutrition and Physical Activity·Benjamin SinghLaurent Gergele
Aug 11, 2020·Irish Journal of Medical Science·Dilek KucukvardarTugba Yavuzsen
May 26, 2021·Medicine and Science in Sports and Exercise·Marlou Floor KenkhuisMartijn J L Bours
Nov 21, 2021·Clinical Journal of Oncology Nursing·Rachel HirscheyCarmina Valle

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