Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.

The Journal of Biological Chemistry
Masato MaesakoAyae Kinoshita

Abstract

Accumulating evidence suggests that some dietary patterns, specifically high fat diet (HFD), increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions targeting HFD-induced metabolic dysfunctions may be effective in preventing the development of AD. We previously demonstrated that amyloid precursor protein (APP)-overexpressing transgenic mice fed HFD showed worsening of cognitive function when compared with control APP mice on normal diet. Moreover, we reported that voluntary exercise ameliorates HFD-induced memory impairment and β-amyloid (Aβ) deposition. In the present study, we conducted diet control to ameliorate the metabolic abnormality caused by HFD on APP transgenic mice and compared the effect of diet control on cognitive function with that of voluntary exercise as well as that of combined (diet control plus exercise) treatment. Surprisingly, we found that exercise was more effective than diet control, although both exercise and diet control ameliorated HFD-induced memory deficit and Aβ deposition. The production of Aβ was not different between the exercise- and the diet control-treated mice. On the other hand, exercise specifically strengthened the activity of neprilysin, the Aβ-degrading en...Continue Reading

References

Jan 12, 1995·Nature·S A NeeperC Cotman
Mar 20, 2001·Archives of Neurology·D LaurinK Rockwood
Aug 8, 2002·Archives of Neurology·Jose A LuchsingerRichard Mayeux
Sep 12, 2002·Archives of Neurology·Hiroaki FukumotoMichael C Irizarry
Jan 24, 2003·Journal of Neural Transmission·V SolfrizziA Capurso
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rena LiYong Shen
Mar 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lap HoGiulio Maria Pasinetti
Oct 12, 2005·Archives of Neurology·Miia KivipeltoAulikki Nissinen
Nov 16, 2005·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·G Stennis WatsonSuzanne Craft
Mar 7, 2006·Experimental Neurology·Ward A PedersenGleb R Haynatzki
Mar 17, 2006·Nature·Sylvain LesnéKaren H Ashe
Apr 20, 2006·Annals of Neurology·Nikolaos ScarmeasJose A Luchsinger
Jan 3, 2007·Journal of the American Geriatrics Society·Francesco PanzaVincenzo Solfrizzi
Apr 14, 2007·Current Alzheimer Research·Rachel A WhitmerKristine Yaffe
Sep 12, 2007·Neurology·Nikolaos ScarmeasYaakov Stern
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John B RoseEliezer Masliah
Mar 11, 2009·Archives of Neurology·Annette L FitzpatrickJosé A Luchsinger
Apr 30, 2009·Annual Review of Nutrition·Faidon MagkosChristos S Mantzoros
Jan 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuan-Shih HuOrly Lazarov
Jun 24, 2010·Neurobiology of Aging·April J HoUNKNOWN ADNI
Sep 23, 2010·Journal of Alzheimer's Disease : JAD·Verena H Finder
Jan 13, 2011·Current Alzheimer Research·A M Tucker, Y Stern
May 31, 2011·The Journal of Biological Chemistry·Masato MaesakoAyae Kinoshita

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Citations

Feb 1, 2013·The New England Journal of Medicine·Monte S Willis, Cam Patterson
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Anchalee Prasansuklab, Tewin Tencomnao
Feb 25, 2014·Ageing Research Reviews·Li Liu, Christina Chan
Jul 8, 2014·Psychoneuroendocrinology·Juan Jose Ramos-RodriguezMonica Garcia-Alloza
Apr 15, 2014·Brain, Behavior, and Immunity·Alyson A Miller, Sarah J Spencer
Jun 5, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zsuzsanna TucsekAnna Csiszar
Feb 10, 2016·European Journal of Epidemiology·Hiro KishimotoYutaka Kiyohara
Nov 26, 2015·Neuroscience and Biobehavioral Reviews·Juan F Codocedo, Nibaldo C Inestrosa
May 16, 2015·Molecular Neurobiology·Juan F CodocedoNibaldo C Inestrosa
Jun 16, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lianne J Trigiani, Edith Hamel
Apr 21, 2018·Journal of Exercise Nutrition & Biochemistry·Jae-Hoon Jeong, Eun-Bum Kang
Jun 12, 2018·Physiological Reports·Bradley J BaranowskiRebecca E K MacPherson
May 5, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bradley J Baranowski, Rebecca E K MacPherson
May 15, 2013·Orvosi hetilap·Gyöngyvér Lacza, Zsolt Radák
Dec 10, 2019·Brain : a Journal of Neurology·Tomoyuki TaguchiRyosuke Takahashi
Feb 24, 2015·Metabolic Brain Disease·Hiranya PintanaSiriporn Chattipakorn
Feb 19, 2019·Journal of Alzheimer's Disease : JAD·Alberto Serrano-Pozo, John H Growdon
Apr 30, 2013·Expert Review of Neurotherapeutics·David Blum, Luc Buée
Nov 7, 2018·Journal of Neuroinflammation·V Alexandra MoserChristian J Pike

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