Exercise-mediated peripheral tissue and whole-body amino acid metabolism during intravenous feeding in normal man

Clinical Science
J D AlbertS F Lowry

Abstract

1. The effect of a daily submaximal exercise regimen on whole-body and peripheral tissue amino acid metabolism during weight-stable intravenous feeding (IVF) was evaluated in 11 normal volunteers. Five of the subjects performed 1 h of daily bicycle exercise at 75 W during IVF, while the remaining six subjects received IVF without daily exercise. Body nitrogen balance, leg and forearm plasma amino acid flux and whole-body kinetics were measured before and on day 10 of IVF using a [1-13C]leucine and [15N]glycine tracer. 2. At the end of the IVF period, exercised subjects demonstrated leg uptake of total amino acids (237 +/- 103 nmol min-1 100 ml-1 of tissue, mean +/- SEM) which was significantly (P less than 0.05) different than in non-exercised subjects (-1101 +/- 253 nmol min-1 100 ml-1 of tissue). 3. In the non-exercised forearm, a significant (P less than 0.05) decrease in total amino acid flux was observed in exercised subjects (-162 +/- 88 nmol min-1 100 ml-1 of tissue) compared with non-exercised subjects (-460 +/- 105 nmol min-1 100 ml-1 of tissue) on day 10 of IVF. 4. Efflux of 3-methylhistidine significantly (P less than 0.05) decreased from the leg in those subjects who performed daily exercise (-0.29 +/- 0.12 nmol min...Continue Reading

Citations

Nov 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·C L Long, S F Lowry
Aug 1, 1991·European Journal of Clinical Investigation·F LundgrenK Lundholm
Nov 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·A C Möller-LoswickK Lundholm
Jan 1, 1991·The American Journal of Physiology·B ArfvidssonK Lundholm
Sep 1, 1990·Baillière's Clinical Endocrinology and Metabolism·K Smith, M J Rennie
Mar 8, 2002·Nutrition·Joanna L Bowtell, Mark Bruce

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