Abstract
To examine whether 12 months of aerobic training (AT) moderated the relationship between change in mobility and change in basal ganglia volume than balance and toning (BAT) exercises in older adults. Secondary analysis of a randomized controlled trial. Champaign-Urbana, Illinois. Community-dwelling older adults (N=101; mean age 66.4). Twelve-month exercise trial with two groups: AT and BAT. Mobility was assessed using the Timed Up and Go test. Basal ganglia (putamen, caudate nucleus, pallidum) was segmented from T1-weighted magnetic resonance images using the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain Software Library Integrated Registration and Segmentation Tool. Measurements were obtained at baseline and trial completion. Hierarchical multiple regression was conducted to examine whether exercise mode moderates the relationship between change in mobility and change in basal ganglia volume over 12 months. Age, sex, and education were included as covariates. Exercise significantly moderated the relationship between change in mobility and change in left putamen volume. Specifically, for the AT group, volume of the left putamen did not change, regardless of change in mobility. Similarly, in the BAT group,...Continue Reading
References
Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·G BorgR Ceci
Sep 18, 1997·Physical Therapy·R P Di Fabio, R Seay
Aug 26, 1998·Brain : a Journal of Neurology·M Jueptner, C Weiller
Mar 29, 2003·Psychological Science·Stanley Colcombe, Arthur F Kramer
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stanley J ColcombeSteriani Elavsky
Apr 13, 2004·Lancet·Nick C Fox, Jonathan M Schott
Feb 11, 2005·Cerebral Cortex·Naftali RazJames D Acker
Mar 23, 2005·Neurology·A F FotenosR L Buckner
Sep 27, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Caterina RosanoAnne B Newman
Oct 6, 2007·Journal of the American Geriatrics Society·Susan E HardyStephanie A Studenski
Nov 19, 2008·Journal of Neurology·Kaoru TakakusakiMasafumi Yano
Jan 6, 2009·Hippocampus·Kirk I EricksonArthur F Kramer
Jan 27, 2010·Archives of Internal Medicine·Teresa Liu-AmbroseTodd C Handy
Aug 10, 2010·Developmental Neuroscience·Laura ChaddockArthur F Kramer
Oct 5, 2010·Frontiers in Aging Neuroscience·Michelle W VossArthur F Kramer
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kirk I EricksonArthur F Kramer
Mar 1, 2011·NeuroImage·Brian PatenaudeMark Jenkinson
Jul 12, 2011·Neurobiology of Aging·Teresa Liu-AmbroseTodd C Handy
Aug 23, 2011·American Journal of Preventive Medicine·Edward McAuleyArthur F Kramer
Apr 17, 2012·Academic Radiology·Xiaojing LongLijuan Zhang
Apr 25, 2012·Archives of Internal Medicine·Lindsay S NagamatsuTeresa Liu-Ambrose
Dec 6, 2012·Translational Neurodegeneration·Toni L PitcherTim J Anderson
Jun 26, 2013·Journal of the American Geriatrics Society·Michele L CallisayaVelandai K Srikanth
Feb 14, 2014·Journal of the American Geriatrics Society·Neha P GotheEdward McAuley
Apr 9, 2014·British Journal of Sports Medicine·Lisanne F ten BrinkeTeresa Liu-Ambrose
Jul 13, 2014·The American Journal of Medicine·Vincentius J A VerlindenM Arfan Ikram
Aug 6, 2014·PloS One·Kuniaki KiuchiToshifumi Kishimoto
Citations
Jul 26, 2016·Frontiers in Human Neuroscience·Mark A FletcherMonica Fabiani
Feb 13, 2019·Journal of Aging and Physical Activity·Lena HübnerClaudia Voelcker-Rehage
Sep 19, 2017·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Lena Hübner, Claudia Voelcker-Rehage
Feb 20, 2020·Journal of Women & Aging·Krystal M PerkinsLuis Velazquez
Sep 8, 2019·NeuroImage. Clinical·Alexa HaegerKathrin Reetz
Mar 1, 2021·Neurobiology of Aging·Marissa A GogniatL Stephen Miller
Apr 17, 2021·Sports Medicine·Lars G HvidUlrik Dalgas