Exercise Mode Moderates the Relationship Between Mobility and Basal Ganglia Volume in Healthy Older Adults

Journal of the American Geriatrics Society
Lindsay S NagamatsuEdward McAuley

Abstract

To examine whether 12 months of aerobic training (AT) moderated the relationship between change in mobility and change in basal ganglia volume than balance and toning (BAT) exercises in older adults. Secondary analysis of a randomized controlled trial. Champaign-Urbana, Illinois. Community-dwelling older adults (N=101; mean age 66.4). Twelve-month exercise trial with two groups: AT and BAT. Mobility was assessed using the Timed Up and Go test. Basal ganglia (putamen, caudate nucleus, pallidum) was segmented from T1-weighted magnetic resonance images using the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain Software Library Integrated Registration and Segmentation Tool. Measurements were obtained at baseline and trial completion. Hierarchical multiple regression was conducted to examine whether exercise mode moderates the relationship between change in mobility and change in basal ganglia volume over 12 months. Age, sex, and education were included as covariates. Exercise significantly moderated the relationship between change in mobility and change in left putamen volume. Specifically, for the AT group, volume of the left putamen did not change, regardless of change in mobility. Similarly, in the BAT group,...Continue Reading

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Citations

Jul 26, 2016·Frontiers in Human Neuroscience·Mark A FletcherMonica Fabiani
Sep 19, 2017·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Lena Hübner, Claudia Voelcker-Rehage
Feb 20, 2020·Journal of Women & Aging·Krystal M PerkinsLuis Velazquez

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