Exercise performance and ventilatory efficiency in patients with mild and moderate liver cirrhosis

Clinical and Experimental Pharmacology & Physiology
K TerziyskiS Kostianev

Abstract

1. The impact of ventilatory efficiency on reduced exercise capacity and recovery oxygen kinetics has not been addressed in cirrhotic patients. The aim of the present study was to investigate exercise performance and ventilatory efficiency in patients with mild and moderate liver cirrhosis (LC). 2. Nineteen male non-hypoxic patients with LC (age 51.3 +/- 9.1 years; body mass index (BMI) 25.6 +/- 3.6 kg/m(2)) classified by the Child-Pugh score as class A (n = 7) and class B (n = 12) and 19 age- and BMI-matched controls participated in the study. Subjects undertook maximal incremental exercise testing on a treadmill using the Bruce protocol. 3. Patients with LC showed a reduced diffusion capacity (D(L,CO)%) compared with controls (74.6 +/- 15.2 vs 95.6 +/- 12.9%, respectively; P < 0.001), but a comparable volume standardized diffusion coefficient (1.33 +/- 0.22 vs 1.45 +/- 0.18 mmol/min per kPa per L, respectively; P = 0.74). Patients with LC had a significantly lower exercise capacity compared with controls (VO(2 max) 23.8 +/- 3.8 vs 30.6 +/- 4.4 mL/min per kg, respectively; P < 0.001). Recovery oxygen kinetics were also impaired in LC patients compared with controls (104.6 +/- 19.3 vs 84.4 +/- 22.7 s, respectively; P = 0.012). ...Continue Reading

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Citations

Feb 26, 2010·BMC Blood Disorders·Montarat ThavorncharoensapBang-On Ubol
Nov 19, 2017·Langenbeck's Archives of Surgery·Sarah Walcott-Sapp, Kevin G Billingsley
Mar 7, 2021·International Journal of Molecular Sciences·Hiroki NishikawaHiroko Iijima
May 1, 2021·International Journal of Environmental Research and Public Health·Thays C SilvaRaphael F de Souza

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