Exercise preconditioning prevents left ventricular dysfunction and remodeling in monocrotaline-induced pulmonary hypertension

Porto Biomedical Journal
Cristine SchmidtDaniel Moreira-Gonçalves

Abstract

Despite pulmonary arterial hypertension (PAH) directly affects the right ventricle (RV), important structural, functional, and molecular changes also occur in left ventricle (LV). The objective of our study was to analyze the hypothetical cardioprotective effects of exercise preconditioning on LV in rats with monocrotaline (MCT)-induced PAH. Forty male Wistar rats were randomly separated in sedentary (SED) and trained group (EX; running sessions of 60 min/day, 5 days/wk, at 25 m/min, for 4 weeks). After 4 weeks, animals were injected with MCT (60 mg/kg; SED + MCT; EX + MCT) or vehicle (SED + V). Following an additional period of 4 weeks where all animals remained sedentary, we completed LV hemodynamic evaluation in baseline and isovolumic conditions and collected LV samples for histological and molecular analysis. Preconditioning with exercise was capable to restore LV systolic and diastolic dysfunction in both baseline and isovolumic conditions (P < .05). This improved was paralleled with prevention of LV cardiomyocytes atrophy, fibrosis, and endothelin 1 mRNA levels (P < .05). Our findings suggest that exercise preconditioning can prevent LV dysfunction secondary to MCT-induced PAH, which is of particular interest for the fam...Continue Reading

References

Jul 1, 1997·Journal of Cardiovascular Pharmacology·Y KasaharaT Kuriyama
Oct 20, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·A E Schultze, R A Roth
Dec 16, 2003·Journal of Applied Physiology·Shannon L LennonScott K Powers
Aug 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Tiago Henriques-CoelhoAdelino F Leite-Moreira
Nov 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·C Tji-Joong GanAnton Vonk-Noordegraaf
May 9, 2006·American Journal of Physiology. Heart and Circulatory Physiology·André P LourençoAdelino F Leite-Moreira
Apr 24, 2008·Clinical and Experimental Pharmacology & Physiology·Maristela P Souza-RabboAdriane Belló-Klein
Mar 17, 2009·Basic Research in Cardiology·Jorge Correia-PintoAdelino F Leite-Moreira
Feb 19, 2011·Journal of the American College of Cardiology·Louis J Dell'Italia
Aug 10, 2011·The Journal of Cell Biology·Pamela A Harvey, Leslie A Leinwand
Oct 25, 2011·Journal of the American College of Cardiology·Arantxa GonzálezJavier Díez
Dec 3, 2011·Journal of the American College of Cardiology·Mariëlle C van de VeerdonkAnton Vonk-Noordegraaf
Jun 9, 2012·Journal of the American College of Cardiology·Maxim HardziyenkaHanno L Tan
Jul 7, 2014·Journal of the American College of Cardiology·Emmy MandersCoen A C Ottenheijm
Oct 16, 2015·Basic Research in Cardiology·Daniel Moreira-GonçalvesTiago Henriques-Coelho
Nov 26, 2015·International Journal of Cardiology·Rita Nogueira-FerreiraTiago Henriques-Coelho
Feb 3, 2016·Heart Failure Reviews·Mariëlle C van de VeerdonkNorbert F Voelkel
May 19, 2016·Expert Review of Respiratory Medicine·Abraham Samuel BabuCarl J Lavie
Oct 13, 2017·Advances in Experimental Medicine and Biology·Daniel Moreira-GonçalvesTiago Henriques-Coelho
Jan 10, 2019·Journal of Cardiopulmonary Rehabilitation and Prevention·Joshua G WoolstenhulmeRandall E Keyser

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
PCR

Software Mentioned

PVAN3
Millar conductance
Image
Pro Plus
ImageJ
Graph Pad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.