Exercise Promotes the Osteoinduction of HA/β-TCP Biomaterials via the Wnt Signaling Pathway

Metabolites
Lijia ChengLiang Zou

Abstract

To investigate the osteoinductive mechanism triggered by hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) biomaterials in mice which keep exercising. Methods: The HA/β-TCP biomaterials were implanted in the muscle of bilateral thighs (non-osseous sites) of eighty Balb/C mice. All animals were then randomly divided into 4 groups (n = 20). In group 1 (negative control group), the mice were fed routinely. In group 2 (running group), all mice were put on a treadmill which was set to a 60-degree incline. The mice ran 20 min thrice each day. A 5-minute break was included in the routine from day three onwards. In group 3 (weight-bearing group), all mice underwent weight-bearing running. The mice in this group performed the same routine as group 2 while carrying 5 g rubber weights. In group 4 (positive control group), dexamethasone was injected in the implanted sites of the biomaterials from the day of the operation. All mice were injected once per week and received a total of 8 injections. One and eight weeks after surgery, the blood serum was collected to detect inflammatory and immunological factors by ELISA. In addition to this, biomaterial specimens were obtained to observe inflammatory and osteogenic levels via histological stain...Continue Reading

References

Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Aug 12, 2014·Scandinavian Journal of Medicine & Science in Sports·M TveitM K Karlsson
Feb 28, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Gabriele ZuchtriegelChristoph A Reichel
Mar 8, 2016·Bone·Florence LoiStuart B Goodman
May 24, 2016·The International Journal of Biochemistry & Cell Biology·Peipei Duan, L F Bonewald
Jun 6, 2016·Trends in Molecular Medicine·Manja Idorn, Pernille Hojman
Nov 7, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Hsin-Ling YangYou-Cheng Hseu
Dec 7, 2016·The Journal of Craniofacial Surgery·Chuang ZhaoEn Luo
Dec 16, 2016·International Journal of Molecular Sciences·Ruilong ZhaoMeilang Xue
Apr 30, 2017·Results and Problems in Cell Differentiation·Girish J Kotwal, Sufan Chien
May 24, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Lijia ChengZheng Shi
Jun 21, 2017·Archives of Physical Medicine and Rehabilitation·Christina L EkegrenBelinda J Gabbe
Jul 5, 2017·Biochemical Society Transactions·Pernille Hojman
Dec 16, 2017·Experimental & Molecular Medicine·Laura McEnerneyTakeshi Saito
Jan 16, 2018·International Journal of Medical Sciences·Antonio BoccaccioApollonia Desiate
Feb 23, 2019·Frontiers in Endocrinology·Giovanni LombardiGiuseppe Banfi
Mar 20, 2019·Sub-cellular Biochemistry·Mark RossGeraint Florida-James
Apr 17, 2019·Bio-medical Materials and Engineering·Lijia ChengZheng Shi

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Citations

Aug 18, 2020·BioMed Research International·Ahmad Taha KhalafXiaoming Liu
Mar 9, 2021·BioMed Research International·Ahmad Taha KhalafXiaoming Liu
Apr 4, 2021·International Journal of Molecular Sciences·Ramsha ShamsNarendra L Banik
Jun 26, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xianghe ChenChengye Liu

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Methods Mentioned

BETA
scanning electron microscopy
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS
ImageJ

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