Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle

The Journal of Physiology
Lisa ColesArend Bonen

Abstract

We examined the effect of a single exercise session on the protein and mRNA expression of the monocarboxylate transporters MCT1 and MCT4 in rat soleus (SOL), and red (RG) and white gastrocnemius (WG) muscles. Muscle samples were obtained at rest before 2 h of treadmill exercise (21 m min(-1), 15% grade) and immediately after exercise, as well as 5, 10 and 24 h after exercise. During the 2 h exercise bout, MCT1 proteins in RG (+60%) and WG (+56%) were increased (P < 0.05). MCT1 protein was further increased thereafter, with peak increments occurring 10 h after exercise in RG (+157%), WG (+193%) and SOL (+179%) (P < 0.05). Twenty-four hours after exercise, MCT1 protein was still up-regulated in WG (+100%) and SOL (+55%) (P < 0.05), but not in RG. MCT1 mRNA was up-regulated during exercise in RG (+53%) and WG (+98%) and remained elevated until 24 h post-exercise in RG (P < 0.05), but in WG, MCT1 mRNA decreased transiently to pre-exercise levels at 5 and 10 h after exercise, before increasing again at 24 h (+150%) (P < 0.05). MCT4 protein and mRNA were not increased in WG muscle during and after exercise (P > 0.05). In contrast, during exercise, in RG (+41%) and SOL (+98%) MCT4 protein was increased (P < 0.05). Peak increases in MC...Continue Reading

References

Jan 27, 1995·The Journal of Biological Chemistry·C K GarciaJ L Goldstein
Mar 9, 1996·Molecular and Cellular Biochemistry·K J McCullaghA Bonen
Jul 1, 1996·The American Journal of Physiology·K J McCullaghA Bonen
Apr 1, 1997·Physiological Reviews·C Juel
Aug 1, 1997·The American Journal of Physiology·K J McCullaghA Bonen
Feb 12, 1998·The American Journal of Physiology·A BonenG J Heigenhauser
Mar 24, 1998·Annual Review of Medicine·L J Goodyear, B B Kahn
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·L PellerinP J Magistretti
Jun 20, 1998·The Journal of Biological Chemistry·M C WilsonA P Halestrap
Feb 10, 1999·The American Journal of Physiology·H PilegaardJ Bangsbo
May 18, 1999·The American Journal of Physiology·H PilegaardC Juel
Nov 24, 1999·Journal of Applied Physiology·G A BrooksH Dubouchaud
Apr 6, 2000·American Journal of Physiology. Endocrinology and Metabolism·H DubouchaudG A Brooks
May 9, 2000·The Journal of Biological Chemistry·A BonenN N Tandon
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·A BonenA P Halestrap
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·M ZhouP F Pilch
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·H PilegaardP D Neufer
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·A BonenA P Halestrap
Dec 1, 2001·The Journal of Biological Chemistry·Gregory R SteinbergArend Bonen
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·H GreenJ Ouyang
Feb 1, 2002·European Journal of Applied Physiology·A Bonen
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Mio TonouchiArend Bonen
Dec 21, 2002·Acta Physiologica Scandinavica·K SepponenA R Pösö
Feb 4, 2003·The Journal of Physiology·Henriette PilegaardP Darrell Neufer
May 10, 2003·Pflügers Archiv : European journal of physiology·Andrew P Halestrap, David Meredith
Aug 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Yuxiang WangArend Bonen
Aug 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·Audrey L HildebrandtP Darrell Neufer
May 18, 2004·Current Opinion in Cell Biology·Elizabeth P Murchison, Gregory J Hannon
May 18, 2004·Current Opinion in Cell Biology·Shiv I S Grewal, Judd C Rice
May 18, 2004·Current Opinion in Cell Biology·Séverine Chambeyron, Wendy A Bickmore
May 18, 2004·Current Opinion in Cell Biology·Nick Proudfoot
May 18, 2004·Current Opinion in Cell Biology·Kristian E Baker, Roy Parker
May 18, 2004·Current Opinion in Cell Biology·Veronique Van de Bor, Ilan Davis
May 18, 2004·Current Opinion in Cell Biology·Yi-Shuian Huang, Joel D Richter
May 18, 2004·Current Opinion in Cell Biology·James E Dahlberg, Elsebet Lund
Sep 8, 2004·Biochemical and Biophysical Research Communications·Carley R BentonArend Bonen

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Citations

Oct 18, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Daniel E Warren, Donald C Jackson
Jan 13, 2006·European Journal of Applied Physiology·Dale C BickhamDavid Cameron-Smith
Feb 4, 2006·European Journal of Applied Physiology·Carsten Juel
Jun 10, 2011·European Journal of Applied Physiology·Claire ThomasChristine Hanon
Mar 13, 2013·The Journal of Clinical Investigation·Lihong JiangGraeme F Mason
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D Meredith, H C Christian
Aug 28, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Adam K Ngan, Yuxiang S Wang
Nov 26, 2015·Clinics in Liver Disease·Laura JopsonDavid E J Jones
Apr 2, 2008·Medicine and Science in Sports and Exercise·Takeshi Hashimoto, George A Brooks
Apr 11, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Arend BonenHideo Hatta
Mar 31, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takeshi HashimotoGeorge A Brooks
Jul 25, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Howard J GreenJing Ouyang
Mar 13, 2014·Journal of Applied Physiology·Masaki Takimoto, Taku Hamada
Sep 12, 2013·American Journal of Physiology. Endocrinology and Metabolism·Avigdor LeftinLucio Frydman
Dec 7, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H J GreenJ Ouyang
Jan 13, 2018·European Journal of Applied Physiology·Brian S FergusonL Bruce Gladden
Oct 21, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Claire ThomasGeorge A Brooks
Mar 29, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Teye Omlin, Jean-Michel Weber
Mar 28, 2013·American Journal of Veterinary Research·Yu KitaokaHideo Hatta
May 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Takashi MatsuiHideaki Soya
Jul 27, 2020·Translational Animal Science·Andrew F WilliamsJennifer M Thomson
Dec 6, 2005·The Journal of Experimental Biology·Andrew PhilpPeter W Watt

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