Exercise, redox homeostasis and the epigenetic landscape.

Redox Biology
Ivan DimauroDaniela Caporossi

Abstract

Physical exercise represents one of the strongest physiological stimuli capable to induce functional and structural modifications in all biological systems. Indeed, beside the traditional genetic mechanisms, physical exercise can modulate gene expression through epigenetic modifications, namely DNA methylation, post-translational histone modification and non-coding RNA transcripts. Initially considered as merely damaging molecules, it is now well recognized that both reactive oxygen (ROS) and nitrogen species (RNS) produced under voluntary exercise play an important role as regulatory mediators in signaling processes. While robust scientific evidences highlight the role of exercise-associated redox modifications in modulating gene expression through the genetic machinery, the understanding of their specific impact on epigenomic profile is still at an early stage. This review will provide an overview of the role of ROS and RNS in modulating the epigenetic landscape in the context of exercise-related adaptations.

Citations

Feb 14, 2021·European Journal of Clinical Investigation·Jorge BelezaJosé Magalhães
May 27, 2021·Antioxidants & Redox Signaling·Amaya Lopez-PascualPedro González-Muniesa
Aug 26, 2021·Antioxidants & Redox Signaling·Clément CrochemoreMiria Ricchetti
Aug 28, 2021·International Journal of Molecular Sciences·Francesca LatinoFrancesco Fischetti

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Methods Mentioned

BETA
acetylation
histone acetylation
ubiquitination
gastric bypass
deamination
sumoylation

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