PMID: 38969May 21, 1979

Exercise responses of healthy subjects in the evaluation of cardioselectivity of beta-blockers

European Journal of Clinical Pharmacology
K L WoodsR J Grieve


The effects of intravenous propranolol, metoprolol, acebutolol and placebo on exercise-induced changes in heart rate and peak flow rate (PFR) have been studied in a group of healthy subjects. The three beta-blockers produced significant and comparable reductions in exercise-induced tachycardia and the magnitude of the reduction was related to the log plasma concentration of each drug. Significant cardiac beta-blockade was detectable for three hours after giving propranolol and for four hours after metoprolol and acebutolol. The exercise-induced changes in PFR were small and variable and were not significantly affected by any of the drugs. We conclude that, contrary to published reports, exercise-induced changes in heart rate and PFR in healthy subjects do not provide a satisfactory test system for assessing the selectivity of beta-blockers.


Jan 1, 1983·Pharmacology & Therapeutics·M J Kendall, L Beeley
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·M J Kendall, S R Smith
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·J A SimoneauC Bouchard
Jan 1, 1981·European Journal of Applied Physiology and Occupational Physiology·H A DavisJ Bassett
Nov 28, 2019·American Journal of Speech-language Pathology·Dallin J BaileyJulie L Wambaugh
Dec 1, 1982·British Journal of Clinical Pharmacology·M J KendallD J Worthington


Feb 1, 1978·British Journal of Clinical Pharmacology·D G McDevitt
Feb 1, 1978·British Heart Journal·P B DecalmerG S Sterling
May 1, 1978·British Journal of Clinical Pharmacology·M K BensonG S Sterling
Jul 19, 1975·Lancet·C R KumanaJ Hamer
Jun 1, 1976·British Journal of Clinical Pharmacology·M J WestE B Faragher
Feb 1, 1975·British Journal of Clinical Pharmacology·M F Cuthbert, R F Collins
Jun 1, 1973·British Journal of Pharmacology·B BasilD R Maxwell
Sep 1, 1973·British Journal of Pharmacology·R H BriantC F George
Nov 23, 1974·British Medical Journal·C R KumanaD M Smith
Jan 1, 1970·Clinical Pharmacology and Therapeutics·D G ShandJ A Oates

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