PMID: 38969May 21, 1979

Exercise responses of healthy subjects in the evaluation of cardioselectivity of beta-blockers

European Journal of Clinical Pharmacology
K L WoodsR J Grieve

Abstract

The effects of intravenous propranolol, metoprolol, acebutolol and placebo on exercise-induced changes in heart rate and peak flow rate (PFR) have been studied in a group of healthy subjects. The three beta-blockers produced significant and comparable reductions in exercise-induced tachycardia and the magnitude of the reduction was related to the log plasma concentration of each drug. Significant cardiac beta-blockade was detectable for three hours after giving propranolol and for four hours after metoprolol and acebutolol. The exercise-induced changes in PFR were small and variable and were not significantly affected by any of the drugs. We conclude that, contrary to published reports, exercise-induced changes in heart rate and PFR in healthy subjects do not provide a satisfactory test system for assessing the selectivity of beta-blockers.

References

Jan 1, 1983·Pharmacology & Therapeutics·M J Kendall, L Beeley
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·M J Kendall, S R Smith
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·J A SimoneauC Bouchard
Jan 1, 1981·European Journal of Applied Physiology and Occupational Physiology·H A DavisJ Bassett
Nov 28, 2019·American Journal of Speech-language Pathology·Dallin J BaileyJulie L Wambaugh
Dec 1, 1982·British Journal of Clinical Pharmacology·M J KendallD J Worthington

Citations

Feb 1, 1978·British Journal of Clinical Pharmacology·D G McDevitt
Feb 1, 1978·British Heart Journal·P B DecalmerG S Sterling
May 1, 1978·British Journal of Clinical Pharmacology·M K BensonG S Sterling
Jul 19, 1975·Lancet·C R KumanaJ Hamer
Jun 1, 1976·British Journal of Clinical Pharmacology·M J WestE B Faragher
Feb 1, 1975·British Journal of Clinical Pharmacology·M F Cuthbert, R F Collins
Jun 1, 1973·British Journal of Pharmacology·B BasilD R Maxwell
Sep 1, 1973·British Journal of Pharmacology·R H BriantC F George
Nov 23, 1974·British Medical Journal·C R KumanaD M Smith
Jan 1, 1970·Clinical Pharmacology and Therapeutics·D G ShandJ A Oates

Related Concepts

Tissue Specificity
Cardiopulmonary Exercise Test
Metoprolol
Heart
Propranolol
Acebutolol
Blockade
Double-Blind Method
Adrenergic beta-Antagonists
Respiratory Function Tests

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.