Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis

Life Sciences
Jim CormierGlenn Stevenson

Abstract

There is great interest in developing and utilizing non-pharmacological/non-invasive forms of therapy for osteoarthritis (OA) pain including exercise and other physical fitness regimens. The present experiments determined the effects of prior wheel running on OA-induced weight asymmetry and trabecular bone microarchitecture. Wheel running included 7 or 21days of prior voluntary access to wheels followed by OA induction, followed by 21days post-OA access to wheels. OA was induced with monosodium iodoacetate (MIA), and weight asymmetry was measured using a hind limb weight bearing apparatus. Bone microarchitecture was characterized using ex vivo μCT. Relative to saline controls, MIA (3.2mg/25μl) produced significant weight asymmetry measured on post-days (PDs) 3, 7, 14, 21 in sedentary rats. Seven days of prior running failed to alter MIA-induced weight asymmetry. In contrast, 21days of prior running resulted in complete reversal of MIA-induced weight asymmetry on all days tested. As a comparator, the opioid agonist morphine (3.2-10mg/kg) dose-dependently reversed weight asymmetry on PDs 3, 7, 14, but was ineffective in later-stage (PD 21) OA. In runners, Cohen's d (effect sizes) for OA vs. controls indicated large increases in b...Continue Reading

References

Jun 1, 1997·Anesthesia and Analgesia·R LikarG Bernatzky
Sep 29, 2004·Osteoarthritis and Cartilage·Laurent GaloisPierre Gillet
Oct 21, 2004·Pain·Janet FernihoughJanet Winter
Apr 2, 2005·Nature Reviews. Drug Discovery·Heike A WielandKarl A Rudolphi
Aug 1, 2006·Annals of the Rheumatic Diseases·R DuncanP Croft
Jun 19, 2007·Arthritis Research & Therapy·Bruce L KiddTheresa Wodehouse
Jun 23, 2007·Pharmacology, Biochemistry, and Behavior·Hilde VermeirschTheo F Meert
Oct 20, 2007·Biological Reviews of the Cambridge Philosophical Society·Shinichi Nakagawa, Innes C Cuthill
Nov 5, 2008·Annals of the Rheumatic Diseases·V B KrausR E Coleman
Jan 16, 2009·European Journal of Pain : EJP·Minna M ElomaaEija A Kalso
Mar 2, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K ChibaH Shindo
Feb 2, 2013·Current Rheumatology Reports·Daniel KrashinJane Ballantyne
Feb 2, 2013·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Stephen P Messier
Jul 17, 2013·BMC Musculoskeletal Disorders·Stephen P MessierRichard F Loeser
Sep 3, 2013·Journal of Graduate Medical Education·Gail M Sullivan, Richard Feinn
Apr 2, 2014·Nature Reviews. Rheumatology·Matthew ThakurRalf Baron
May 6, 2014·Best Practice & Research. Clinical Rheumatology·Victoria L Johnson, David J Hunter
Jun 15, 2014·Osteoarthritis and Cartilage·A BoudenotE Lespessailles
Nov 9, 2014·The Bone & Joint Journal·M E BerendA V Lombardi
Dec 24, 2015·The Journal of Pain : Official Journal of the American Pain Society·Joshua HavelinTamara King
Jan 29, 2016·Pain·Rolf-Detlef Treede
Jun 30, 2016·Pain·Peter M GraceLinda R Watkins

❮ Previous
Next ❯

Citations

Feb 15, 2018·Rheumatology·Hema Urban, Christopher B Little
Jun 25, 2018·Current Osteoporosis Reports·Mark Henry Pitcher
Jan 26, 2021·Pain Reports·Joseph B Lesnak, Kathleen A Sluka
May 25, 2021·The Journal of Pain : Official Journal of the American Pain Society·Emily PayneGlenn W Stevenson
Aug 18, 2021·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Kumiko IshikawaMinoru Okita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.