Exercise stress echocardiography in patients with valvular heart disease

Echo Research and Practice
Vishal SharmaAndrew J Kerr

Abstract

Stress echocardiography is recommended for the assessment of asymptomatic patients with severe valvular heart disease (VHD) when there is discrepancy between symptoms and resting markers of severity. The aim of this study is to determine the prognostic value of exercise stress echocardiography in patients with common valve lesions. One hundred and fifteen patients with VHD (aortic stenosis (n=28); aortic regurgitation (n=35); mitral regurgitation, (n=26); mitral stenosis (n=26)), and age- and sex-matched controls (n=39) with normal ejection fraction underwent exercise stress echocardiography. The primary endpoint was a composite of death or hospitalization for heart failure. Asymptomatic VHD patients had lower exercise capacity than controls and 37% of patients achieved <85% of their predicted metabolic equivalents (METS). There were three deaths and four hospital admissions, and 24 patients underwent surgery during follow-up. An abnormal stress echocardiogram (METS <5, blood pressure rise <20 mmHg, or pulmonary artery pressure post exercise >60 mmHg) was associated with an increased risk of death or hospital admission (14% vs 1%, P<0.0001). The assessment of contractile reserve did not offer additional predictive value. In con...Continue Reading

References

Jul 1, 1991·European Heart Journal·J P DelahayeH Milon
Apr 1, 1988·European Heart Journal·D Horstkotte, F Loogen
Mar 1, 1995·Journal of the American College of Cardiology·M Enriquez-SaranoJ B Seward
Mar 1, 1993·Circulation·M Enriquez-SaranoJ M Mays
Sep 1, 1997·Journal of the American College of Cardiology·E KlodasJ B Seward
Oct 8, 1999·The American Journal of Cardiology·S J LesterE Foster
Nov 1, 2000·Echocardiography·G T SieswerdaC A Visser
Feb 12, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Miguel A QuiñonesUNKNOWN Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
May 8, 1954·British Medical Journal·P WOOD
Apr 12, 2005·European Heart Journal·Paul DasJohn Chambers
May 11, 2005·Circulation·Delphine DetaintMaurice Enriquez-Sarano
Jul 29, 2008·Archives of Cardiovascular Diseases·Sylvestre MaréchauxPierre Vladimir Ennezat
Dec 10, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Helmut BaumgartnerUNKNOWN EAE/ASE
Jul 17, 2010·Journal of the American College of Cardiology·Julien MagneLuc A Piérard
Aug 28, 2012·European Heart Journal·UNKNOWN Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC)Marian Zembala
Sep 10, 2013·European Heart Journal·Julien MagnePatrizio Lancellotti

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

XLSTAT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.