Exercise stress test reveals ineligibility for subcutaneous implantable cardioverter defibrillator in patients with Brugada syndrome

Journal of Cardiovascular Electrophysiology
Motomi TachibanaHiroshi Ito

Abstract

The eligibility of patients with Brugada syndrome (BrS) for implantation of a subcutaneous implantable cardioverter defibrillator (S-ICD) is not well known. This study aimed to clarify the eligibility of BrS patients for S-ICD using electrocardiography (ECG) at rest and during exercise testing. We also analyzed factors associated with ineligibility for S-ICD from standard 12-lead ECG at rest. We enrolled 110 consecutive BrS patients who visited Okayama university hospital from December 2015 to December 2016. All patients were assessed for S-ICD eligibility, which required one lead to satisfy the S-ICD screening template. We assessed standard 12-lead ECG parameters in all participants. Of those who passed S-ICD screening, 45 patients were assessed for S-ICD eligibility during treadmill stress test. Mean age of study patients was 54 ± 13 years and 108 (98%) were men. In total, 89 patients (81%) satisfied S-ICD indications at rest. Existence of complete right bundle branch block (CRBBB) on standard 12-lead ECG was a significant predictor of ineligibility for S-ICD (odds ratio, 5.00; P = 0.03; 95%CI, 1.14-21.98). Of the 45 patients who underwent treadmill stress testing, 11 patients (24%) showed ineligibility for S-ICD during the t...Continue Reading

References

Oct 30, 2010·Journal of the American College of Cardiology·Hisaki MakimotoWataru Shimizu
Mar 8, 2011·Revista española de cardiología·Miguel A AriasLuis Rodríguez-Padial
Oct 14, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Elia De MariaStefano Cappelli
Nov 30, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yutaka TakeHiroshi Ito
Dec 24, 2011·Journal of the American College of Cardiology·Silvia G PrioriMario Colombo
Dec 20, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Daniel A RandlesDavid J Wright
Jun 1, 2015·International Journal of Cardiology·Louise R A Olde NordkampReinoud E Knops
Sep 13, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Niccolo' MauriziFranco Cecchi
Oct 9, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Tadashi WadaTohru Ohe
Jan 30, 2016·Journal of the American College of Cardiology·Geoffrey F Lewis, Michael R Gold
Feb 14, 2016·Journal of the American Heart Association·Jonathan WeinstockMark S Link
Apr 2, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yuka MizusawaArthur A M Wilde
Jun 16, 2016·Arquivos brasileiros de cardiologia·Daniel García-FuertesMiguel Angel Arias
Aug 6, 2016·Journal of the American College of Cardiology·Louise R A Olde NordkampArthur A M Wilde
Jan 11, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Antonio CurcioCiro Indolfi
Mar 21, 2017·Journal of Cardiovascular Electrophysiology·Muthiah SubramanianKumaraswamy Natarajan

❮ Previous
Next ❯

Citations

Jun 7, 2018·Journal of Cardiovascular Electrophysiology·Markus BettinGerrit Frommeyer
Feb 26, 2019·Journal of Arrhythmia·Motomi TachibanaHiroshi Ito
Aug 15, 2020·Clinical Cardiology·Christoph SchukroCesar Khazen
Mar 20, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Nils BögeholzLars Eckardt
Jan 14, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Pedro von HafeAntónio Lourenço

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.