Abstract
Exercise training improves plasma lipid profile and diminishes risk of coronary heart disease. Previously, we showed that training increases LDL plasma clearance, as tested by an artificial LDL-like nanoemulsion method, presumably by increasing LDL receptor activity. In this study, we investigated whether training could also improve LDL clearance in hypercholesterolemic subjects (HCh) that are exposed to increased risk of cardiovascular events. Twenty sedentary HCh and 20 normolipidemic (NL) sedentary volunteers were divided into four groups: 12 HCh submitted to 4-month training program, 8 HCh with no exercise program, 12 NL submitted to 4-month training and 8 NL with no exercise program. An LDL-like nanoemulsion labeled with (14)C-cholesteryl ester was injected intravenously into all subjects and plasma samples were collected during 24 h after injection to determine the fractional clearance rate (FCR, in h(-1)) by compartmental analysis. The study was performed on the first and on the last day of the 4-month study period. In both, trained HCh and NL groups, training increased nanoemulsion FCR by 36% (0.0443+/-0.0126; 0.0602+/-0.0187, p=0.0187 and 0.0503+/-0.0203; 0.0686+/-0.0216, p=0.0827, respectively). After training, LDL ch...Continue Reading
References
Apr 1, 1992·Metabolism: Clinical and Experimental·P T WilliamsP D Wood
Feb 1, 1990·Atherosclerosis·B MartiF Gutzwiller
Jan 1, 1989·Free Radical Research Communications·H EsterbauerM Rotheneder
Apr 3, 1986·Nature·R J GryglewskiS Moncada
Apr 4, 1986·Science·M S Brown, J L Goldstein
Dec 1, 1980·British Journal of Sports Medicine·K NiemeläJ Takkunen
Aug 1, 1993·Lipids·R C MaranhãoC H Mesquita
Sep 27, 1996·Atherosclerosis·R C MaranhãoF Pileggi
Jun 1, 1997·Lipids·R C MaranhãoF Pileggi
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·L L Ji
Feb 9, 2002·Lipids·L B PintoR C Maranhão
Feb 4, 2003·Journal of Lipid Research·Raul D SantosRaul C Maranhão
Jun 26, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·P G SchefferT Teerlink
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Apr 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Beata OlchawaDmitri Sviridov
Nov 16, 2005·International Journal of Sport Nutrition and Exercise Metabolism·Anatoli PetridouVassilis Mougios
Jan 31, 2006·Archives of Physical Medicine and Rehabilitation·Sophie ZieglerMichael Wolzt
Dec 23, 2006·European Journal of Applied Physiology·Susanne Ring-DimitriouErich Mueller
Mar 24, 2007·Metabolism: Clinical and Experimental·Amy HalverstadtJames M Hagberg
Apr 20, 2007·Lipids·Ricardo D CoutoRaul C Maranhão
Jul 14, 2007·Journal of Applied Physiology·Carmen G C VinagreRaul C Maranhão
Aug 11, 2007·Biochemical and Biophysical Research Communications·Abbass Ghanbari-NiakiMehdi Hedayati
Jul 25, 2009·European Journal of Applied Physiology·Behzad Mehdi KhabazianHossein Abednazari
Citations
Feb 3, 2012·Intensive Care Medicine·Sylas B CappiFrancisco G Soriano
Jul 19, 2013·Journal of Lipids·Shin WenTodd C Rideout
Feb 14, 2016·Trials·Marinei Lopes PedralliAlexandre Machado Lehnen
Sep 13, 2011·Atherosclerosis·Jeferson L da SilvaRaul C Maranhão
Jun 6, 2018·Frontiers in Physiology·Paula R PintoMarisa Passarelli
Sep 5, 2019·Oxidative Medicine and Cellular Longevity·André L L BachiRaul C Maranhão