Exercise training as a novel primary treatment for localised prostate cancer: a multi-site randomised controlled phase II study

Scientific Reports
L BourkeDerek J Rosario

Abstract

Alternative management strategies for localised prostate cancer are required to reduce morbidity and overtreatment. The aim of this study was to evaluate the feasibility, safety and acceptability of exercise training (ET) with behavioural support as a primary therapy for low/intermediate risk localised prostate cancer. Men with low/intermediate-risk prostate cancer were randomised to 12 months of ET or usual care with physical activity advice (UCwA) in a multi-site open label RCT. Feasibility included acceptability, recruitment, retention, adherence, adverse events and disease progression. Secondary outcomes included quality of life and cardiovascular health indices. Of the 50 men randomised to ET (n = 25) or UCwA (n = 25), 92% (n = 46) completed 12 month assessments. Three men progressed to invasive therapy (two in UCwA). In the ET group, men completed mean: 140 mins per week for 12 months (95% CI 129,152 mins) (94% of target dose) at 75% Hrmax. Men in the ET group demonstrated improved body mass (mean reduction: 2.0 kg; 95% CI -2.9,-1.1), reduced systolic (mean: 13 mmHg; 95%CI 7,19) and diastolic blood pressure (mean:8 mmHg; 95% CI 5,12) and improved quality of life (EQ.5D mean:13 points; 95% CI 7,18). There were no serious a...Continue Reading

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Citations

Jul 17, 2019·Cancer Causes & Control : CCC·Efthymios PapadopoulosDaniel Santa Mina
May 18, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Aileen MurphyFrances J Drummond
Mar 3, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Júlio Araújo RendeiroKatiane da Costa Cunha
Aug 12, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Efthymios PapadopoulosDaniel Santa Mina

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Methods Mentioned

BETA
biopsy

Software Mentioned

RE
ProtecT
PANTERA
PIVOT

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