Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice

Brain, Behavior, and Immunity
Noriaki KawanishiKatsuhiko Suzuki

Abstract

Nonalcoholic steatohepatitis, which is considered the hepatic event in metabolic syndrome, was recently associated with the innate immune system. Although regular exercise reduces hepatic injury markers like serum alanine aminotransferase (ALT) levels, the mechanisms regulating the effects of exercise on steatohepatitis are unclear. This study aimed to clarify whether exercise training suppresses hepatic injury, inflammation, and fibrosis by suppressing macrophage infiltration. Male C57BL/6J (4-week old) mice were randomly divided into four groups: normal diet (ND) control (n=7), ND exercise (n=5), high-fat diet and high-fructose water (HFF) control (n=11), and HFF exercise (n=11) groups. Mice were fed the ND or HFF from 4 to 20 weeks of age. The exercise groups were trained on a motorized treadmill for 60 min/day, five times/week. The nonalcoholic fatty liver disease (NAFLD) activity score and plasma ALT activity, indicators of liver injury, were increased in HFF control mice but were attenuated in HFF exercise mice. Hepatic inflammation, indicated by hepatic tumor necrosis factor (TNF)-α levels and hepatic resident macrophage infiltration, was significantly lower in HFF exercise mice than in HFF control mice. Hepatic fibrosis...Continue Reading

References

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C P Day, O F James
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donna M DambachDebra L Laskin
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Jul 16, 2004·The Journal of Clinical Investigation·Jeffrey D Browning, Jay D Horton
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Feb 3, 2006·Scandinavian Journal of Medicine & Science in Sports·B K Pedersen, B Saltin
May 19, 2006·Journal of Gastroenterology and Hepatology·Chalamalasetty Sreenivasa BabaGourdas Choudhuri
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gyongyi SzaboPranoti Mandrekar
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Aug 29, 2007·The Journal of Biological Chemistry·Noriko NaraTakahiko Hara
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Machteld M TiemessenLeonie S Taams
Sep 6, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Laura H TetriBrent A Neuschwander-Tetri
Oct 29, 2008·Seminars in Liver Disease·Harmeet Malhi, Gregory J Gores
Mar 12, 2009·American Journal of Physiology. Endocrinology and Metabolism·Victoria J VieiraJeffrey A Woods
Apr 21, 2009·Gastroenterology·Jianhua WangJacob George
May 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ekihiro SekiDavid A Brenner
Jun 9, 2009·Journal of Hepatology·Curtis K ArgoStephen H Caldwell
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karlin Raja KarlmarkFrank Tacke
Jul 28, 2009·Nature Medicine·Shawn WinerH-Michael Dosch
Aug 14, 2009·Expert Review of Gastroenterology & Hepatology·Naim AlkhouriAriel E Feldstein
Oct 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kittichai PromratRena R Wing
Nov 17, 2009·Journal of Hepatology·Yury Popov, Detlef Schuppan
Feb 25, 2010·Journal of Atherosclerosis and Thrombosis·Yukinori TamuraHidenori Arai
Apr 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Jung Sub LimRobert H Lustig
May 22, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C M M MarquesC A Mandarim-de-Lacerda
Jul 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rohit KohliRandy J Seeley
Aug 7, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Samuele De MinicisDavid A Brenner
Sep 28, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Alini SchultzCarlos A Mandarim-de-Lacerda
Sep 28, 2010·World Journal of Gastroenterology : WJG·Yu-Tao Zhan, Wei An
Mar 1, 2011·Brain, Behavior, and Immunity·Bente K Pedersen
Oct 15, 2011·Nature Reviews. Immunology·Peter J Murray, Thomas A Wynn

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Citations

Apr 6, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Jia XiaoGeorge L Tipoe
Nov 20, 2013·Journal of Clinical Biochemistry and Nutrition·Astrid ReicholdStephan C Bischoff
Apr 1, 2014·Trends in Immunology·Graeme I Lancaster, Mark A Febbraio
Nov 28, 2014·Immunotherapy·Vasso ApostolopoulosLily Stojanovska
Aug 6, 2015·Journal of Exercise Nutrition & Biochemistry·Jun Hyun JeongWang Lok Lee
Apr 12, 2013·Mediators of Inflammation·Frederick WasinskiRonaldo C Araujo
Oct 15, 2013·Biochemical and Biophysical Research Communications·Noriaki KawanishiKatsuhiko Suzuki
Aug 8, 2015·Nutrition & Metabolism·Sheril AlexSander Kersten
Apr 4, 2015·Metabolism: Clinical and Experimental·Emanuel PassosJosé Magalhães
Apr 14, 2015·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Rui GuoGeorge L Tipoe
Nov 5, 2014·European Journal of Applied Physiology·Roy J Shephard, Nathan Johnson
Jul 17, 2016·Current Rheumatology Reports·Antonia RuJia SunIndira Prasadam
Feb 9, 2017·Free Radical Research·Rômulo Pillon BarcelosGuilherme Bresciani
Jul 31, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R N SilvaA M O Leal
Feb 12, 2017·Canadian Journal of Physiology and Pharmacology·Nathalia BernardesPawan K Singal
May 24, 2017·Journal of Lipid Research·Aafke W F JanssenSander Kersten
Aug 15, 2018·Physiological Reports·Caroline M KristensenHenriette Pilegaard
Feb 27, 2019·American Journal of Physiology. Endocrinology and Metabolism·Jariya BuniamVitoon Saengsirisuwan
Oct 12, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Débora Romualdo LacerdaAdaliene Versiani Matos Ferreira
Apr 10, 2019·American Journal of Physiology. Endocrinology and Metabolism·Gaël EnnequinMartin Whitham
Jul 2, 2014·Medicine and Science in Sports and Exercise·Melissa A LindenR Scott Rector
Aug 21, 2013·Medicine and Science in Sports and Exercise·Noriaki KawanishiKatsuhiko Suzuki
Dec 28, 2019·Medicine and Science in Sports and Exercise·Yoichi SatoOsamu Ito
May 27, 2014·International Journal of Oncology·Jamie L McClellanE Angela Murphy
Jun 9, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Marta Borges CanhaPedro Pimentel-Nunes
Jul 28, 2020·Alimentary Pharmacology & Therapeutics·Philip O'GormanSuzanne Norris
Aug 24, 2019·Frontiers in Endocrinology·Ru WangTiemin Liu
May 30, 2019·World Journal of Gastrointestinal Oncology·Zeynep Oruç, Muhammed Ali Kaplan

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