Exercise training attenuates neutrophil infiltration and elastase expression in adipose tissue of high-fat-diet-induced obese mice

Physiological Reports
Noriaki KawanishiKatsuhiko Suzuki

Abstract

The innate immune system is associated with the development of local inflammation. Neutrophils play an essential role in the development of the adipose tissue (AT) inflammation associated with obesity by producing elastase, which can promote the activation and infiltration of macrophages. Exercise training attenuates AT inflammation via suppression of macrophage infiltration. However, the mechanisms driving this phenomenon remains to be elucidated. Here, we evaluated the effects of exercise training on the infiltration of neutrophils and elastase expression in an obese mouse model. Four-week-old male C57BL/6J mice were randomly assigned to one of three groups that either received a normal diet (ND) plus sedentary activity (n = 15), a high-fat diet (HFD) plus sedentary activity (n = 15), or a HFD plus exercise training (n = 15). Mice were fed the ND or HFD from the age of 4 weeks until 20 weeks. Mice in the exercise group ran on a treadmill for 60 min/day, 5 days/week over the same experimental period. Mice fed with the HFD had increased content of macrophages in the AT and increased inflammatory cytokine mRNA levels, which were reduced by exercise training. Similarly, AT from the HFD sedentary mice contained more neutrophils th...Continue Reading

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Citations

Oct 12, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Débora Romualdo LacerdaAdaliene Versiani Matos Ferreira
Aug 31, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Timothy S OdermattDaniel Konrad
Feb 13, 2020·Biomedicines·Yvonne Oligschlaeger, Ronit Shiri-Sverdlov
Apr 5, 2018·Scientific Reports·Mariia P RudykLiudmyla I Ostapchenko
Feb 10, 2017·Archives of Dermatological Research·Kende LőrinczNorbert M Wikonkál
Feb 27, 2018·Frontiers in Immunology·William TrimDylan Thompson
Jun 2, 2020·Frontiers in Endocrinology·Andrea Benova, Michaela Tencerova
Jul 30, 2018·Molecular Biology Reports·Mohammad AliSubrata K Biswas
Dec 30, 2020·International Journal of Molecular Sciences·José Cesar Rosa-Neto, Loreana Sanches Silveira
Apr 27, 2021·Obesity·Nathan C WinnAlyssa H Hasty

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Methods Mentioned

BETA
flow cytometry
PCR
fluorescence-activated

Software Mentioned

SPSS
Statistical Package for the Social Sciences
InCyte

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