Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats

Clinical and Experimental Hypertension : CHE
Takuya KishiKenji Sunagawa

Abstract

Exercise training normalizes sympathetic outflow in hypertension and chronic heart failure. The aim of this study was to determine whether the exercise training inhibits sympathetic nerve activity (SNA) via reduction of oxidative stress through blocked angiotensin II type 1 receptor (AT(1)R) in rostral ventrolateral medulla (RVLM). We divided stroke-prone spontaneously hypertensive rats (SHRSP) into SHRSP with exercised training (SHRSP-EX) and control (SHRSP-C). SNA and oxidative stress in the RVLM were significantly lower in SHRSP-EX than in SHRSP-C. These results suggest that exercise training inhibits SNA via reduction of oxidative stress through blocked AT(1)R in the RVLM of hypertension.

References

Apr 1, 1995·Pharmacology, Biochemistry, and Behavior·S M SomaniL P Rybak
Feb 1, 1994·Psychological Reports·H P ParetteT E Smith
Oct 27, 1997·Journal of Applied Toxicology : JAT·S M Somani, K Husain
Jul 14, 2001·Journal of the American College of Cardiology·P V EnnezatT H LeJemtel
Nov 29, 2002·Circulation Research·Matthew C ZimmermanRobin L Davisson
Feb 12, 2004·Journal of Cardiovascular Pharmacology·Yoshitaka HirookaAkira Takeshita
Jul 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Koji SakaiKenji Sunagawa
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Jan 25, 2008·Clinical and Experimental Hypertension : CHE·Takuya KishiKenji Sunagawa
Dec 17, 2009·Clinical and Experimental Hypertension : CHE·Takuya KishiKenji Sunagawa
Jan 23, 2010·Journal of Applied Physiology·Sumit KarIrving H Zucker
Mar 23, 2010·Experimental Physiology·James P Fisher, Paul J Fadel
Feb 25, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshitaka Hirooka

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Citations

Jul 23, 2013·Free Radical Research·Z RadakI Boldogh
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Chang-zhen RenYang-kai Wang
Feb 11, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Naiane F B AlvesValdir A Braga
Feb 26, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E F S CastroM C Irigoyen
Aug 4, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Irving H Zucker, Timothy I Musch
Jul 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Masaki MizunoScott A Smith
Feb 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Irving H ZuckerHanjun Wang
Oct 9, 2015·Brain Plasticity·Sucharita S SomkuwarChitra D Mandyam
May 10, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas A MischelPatrick J Mueller
May 17, 2019·Oxidative Medicine and Cellular Longevity·Danyang Tian, Jinqi Meng

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