Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats

International Journal of Cardiology
Shiu-Min ChengShin-Da Lee

Abstract

Increased myocyte apoptosis in diabetic hearts has been previously reported. The purpose of this study was to evaluate the effects of exercise training on cardiac survival pathways in streptozotocin (STZ)-induced diabetic rats. Forty-eight male Wistar rats were randomly divided into control group (Control), STZ-induced (65 mg/kg, i.p.) diabetes (DM), and DM rats with moderate aerobic exercise training (DM-EX) on a treadmill 60 min/day, 5 days/week, for 10 weeks. Histopathological analysis, positive TUNEL assays and Western blotting were performed on the excised cardiac left ventricles from all three groups. The components of cardiac survival pathway (insulin-like growth factor I (IGFI), IGFI-receptor (IGFI-R), phosphatidylinositol 3'-kinase (PI3K), and Akt) and the pro-survival Bcl-2 family proteins (Bcl-2, Bcl-xL, and p-BAD) were all significantly decreased in the DM group compared with the Control group whereas they were increased in the DM-EX group. In addition, the abnormal myocardial architecture, enlarged interstitial space and increased cardiac TUNEL-positive apoptotic cells were observed in the DM group, but they were reduced in the DM-EX group. The apoptotic key component, caspase-3, was significantly increased in the ...Continue Reading

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Citations

May 16, 2014·International Journal of Cardiology·Mei-Chih LaiShin-Da Lee
May 31, 2015·Vascular Pharmacology·Prasanna Abeyrathna, Yunchao Su
Apr 5, 2016·International Journal of Molecular Sciences·Yung-Ming ChangChih-Yang Huang
Apr 7, 2017·BMC Genetics·Katarzyna Ropka-MolikMonika Bugno-Poniewierska
Jul 11, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathleen SturgeonJoseph R Libonati
Jun 25, 2016·Journal of Applied Physiology·Chih-Yang HuangShin-Da Lee
Jan 30, 2020·British Journal of Pharmacology·Kerstin BoenglerRainer Schulz
Aug 13, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Qianli WangJianchun Wang
Sep 27, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Rodrigo W A SouzaRobson F Carvalho
Apr 21, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Abdelaziz M HusseinLashin S Lashin

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