Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts

American Journal of Physiology. Heart and Circulatory Physiology
Motoyuki IemitsuTakashi Miyauchi

Abstract

Exercise training improves aging-induced deterioration of angiogenesis in the heart. However, the mechanisms underlying exercise-induced improvement of capillary density in the aged heart are unclear. Vascular endothelial growth factor (VEGF) is implicated in angiogenesis, which activated angiogenic signaling cascade through Akt and endothelial nitric oxide synthase (eNOS)-related pathway. We hypothesized that VEGF angiogenic signaling cascade in the heart contributes to a molecular mechanism of exercise training-induced improvement of capillary density in old age. With the use of hearts of sedentary young rats (4 mo old), sedentary aged rats (23 mo old), and exercise-trained aged rats (23 mo old, swim training for 8 wk), the present study investigated whether VEGF and VEGF-related angiogenic molecular expression in the aged heart is affected by exercise training. Total capillary density in the heart was significantly lower in the sedentary aged rats compared with the sedentary young rats, whereas that in the exercise-trained rat was significantly higher than the sedentary aged rats. The mRNA and protein expressions of VEGF and of fms-like tyrosine kinase-1 (Flt-1) and fetal liver kinase-1 (Flk-1), which are main VEGF receptors...Continue Reading

References

Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G ConnK A Thomas
Jan 1, 1987·Annual Review of Physiology·E G Lakatta
Jul 1, 1983·The American Journal of Physiology·J M CapassoE H Sonnenblick
Mar 25, 1983·Nucleic Acids Research·U NudelD Yaffe
Jan 1, 1996·The American Journal of Physiology·L MorbidelliM Ziche
Jan 13, 1999·Circulation·A RivardJ M Isner
Apr 13, 1999·The American Journal of Physiology·H KumamotoA Kitabatake
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Mar 22, 2000·Circulation Research·S Dimmeler, A M Zeiher
Feb 24, 2000·The Medical Clinics of North America·P A Ades, C E Coello
Mar 31, 2000·Nature Medicine·P Carmeliet
Apr 6, 2000·Journal of Applied Physiology·T P GavinP D Wagner
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M IemitsuM Matsuda
Sep 23, 2000·Nature·G D YancopoulosJ Holash
Nov 1, 2000·Cell·A Toker, A C Newton
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·D FukumuraR K Jain
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Subrina JesminAkira Kitabatake
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Motoyuki IemitsuIwao Yamaguchi
Feb 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Subrina JesminAkira Kitabatake
Aug 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Eman Sadoun, May J Reed
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Jay M Edelberg, May J Reed
Aug 31, 2004·Journal of Applied Physiology·Barry M PriorRonald L Terjung
Apr 20, 2005·Journal of Cardiovascular Pharmacology·Subrina JesminTakashi Miyauchi
Nov 4, 2005·Acta Physiologica Scandinavica·M IemitsuH Tanaka

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Citations

Jan 4, 2008·Histochemistry and Cell Biology·Marina MariniArsenio Veicsteinas
Oct 28, 2009·European Journal of Applied Physiology·M Brennan HarrisDavid J Hryvniak
May 17, 2007·Apoptosis : an International Journal on Programmed Cell Death·Kun-Ru ZhangFeng Gao
Aug 21, 2013·Aging Clinical and Experimental Research·Giuseppe RengoDario Leosco
Jul 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sunday OladipupoJeffrey M Arbeit
May 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dario LeoscoFranco Rengo
Mar 4, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jena J SteinleVannak C Chin
Jan 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Noa Valcarcel-AresAnna Csiszar
Jul 12, 2011·Physiological Reviews·Mark A SussmanMichael McGregor
Apr 20, 2011·Expert Review of Proteomics·Hyoung Kyu KimJin Han
Dec 15, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Amanda J LeBlanc, James B Hoying
Feb 5, 2015·Cell Metabolism·Colin PlattAnthony Rosenzweig
Aug 4, 2009·Microvascular Research·Sheepsumon ViboolvorakulSuthiluk Patumraj
Oct 30, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Begoña Villar-ChedaJose L Labandeira-Garcia
Nov 6, 2008·Experimental Gerontology·Christine Le PageSophie Besse
Jun 12, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Stefano Ginanni CorradiniEugenio Gaudio
Jan 1, 2010·Journal of Cellular and Molecular Medicine·Mohsin KhanSheikh Riazuddin
Jun 21, 2015·Ageing Research Reviews·Charles Ambrose
Oct 25, 2011·Neurobiology of Aging·Nivetha MurugesanJoel S Pachter
Mar 19, 2014·Drug Discovery Today·Carolin Lerchenmüller, Anthony Rosenzweig
Jun 12, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S L AmaralL C Michelini
Nov 20, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Richard S SweatWalter L Murfee
Jan 31, 2018·Medicine and Science in Sports and Exercise·Natsuki HasegawaMotoyuki Iemitsu
Apr 28, 2012·Circulation Research·Johanna Lähteenvuo, Anthony Rosenzweig
Feb 4, 2016·Circulation Research·Jason RohAnthony Rosenzweig
Nov 28, 2012·Circulation·Nina Mann, Anthony Rosenzweig
Nov 26, 2008·Sports Medicine·Fung Ping LeungYu Huang
Nov 17, 2009·Medicine and Science in Sports and Exercise·Maxime PellegrinPascal Laurant
May 9, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takeshi OtsukiTakashi Miyauchi
Sep 3, 2019·Archives of Physiology and Biochemistry·Rahman SooriFabrício Azevedo Voltarelli
Apr 17, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ana MuñozJose L Labandeira-Garcia
Aug 10, 2017·Critical Care : the Official Journal of the Critical Care Forum·Karel TymlSean E Gill
Nov 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Eurico N WilhelmMark Rakobowchuk
May 21, 2015·Physiological Reports·Kathleen SturgeonJoseph R Libonati
May 26, 2018·Nature Reviews. Cardiology·Zoltan UngvariAnna Csiszar

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