Exercise training in Diastolic Heart Failure (Ex-DHF): rationale and design of a multicentre, prospective, randomized, controlled, parallel group trial

European Journal of Heart Failure
F EdelmannBurkert Pieske

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a common disease with high incidence and increasing prevalence. Patients suffer from functional limitation, poor health-related quality of life, and reduced prognosis. A pilot study in a smaller group of HFpEF patients showed that structured, supervised exercise training (ET) improves maximal exercise capacity, diastolic function, and physical quality of life. However, the long-term effects of ET on patient-related outcomes remain unclear in HFpEF. The primary objective of the Exercise training in Diastolic Heart Failure (Ex-DHF) trial is to investigate whether a 12 month supervised ET can improve a clinically meaningful composite outcome score in HFpEF patients. Components of the outcome score are all-cause mortality, hospitalizations, NYHA functional class, global self-rated health, maximal exercise capacity, and diastolic function. After undergoing baseline assessments to determine whether ET can be performed safely, 320 patients at 11 trial sites with stable HFpEF are randomized 1:1 to supervised ET in addition to usual care or to usual care alone. Patients randomized to ET perform supervised endurance/resistance ET (3 times/week at a certified training centre) for 1...Continue Reading

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Citations

Apr 6, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Flavia BaldassarriAndré Duvinage
May 8, 2018·Postgraduate Medical Journal·Mark Abela
Dec 12, 2017·Current Opinion in Cardiology·Kegan J MoneghettiFrancois Haddad
Jan 30, 2019·The Cochrane Database of Systematic Reviews·Linda LongRod S Taylor
Jul 26, 2019·European Journal of Heart Failure·Massimo F PiepoliUNKNOWN Committee on Exercise Physiology & Training of the Heart Failure Association of the European Society of Cardiology
Mar 9, 2019·Cardiac Failure Review·Jacqueline H Morris, Leway Chen
Jun 5, 2019·Current Heart Failure Reports·Michael Johannes SchindlerMartin Halle
Aug 23, 2019·Der Internist·Johannes Petutschnigg, Frank Edelmann
Jun 11, 2019·European Journal of Preventive Cardiology·Birna Bjarnason-WehrensUNKNOWN German Society of Cardiovascular Prevention and Rehabilitation (DGPR)
Apr 3, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jan WintrichMichael Böhm
Jun 10, 2020·Current Heart Failure Reports·Elizabeth EpsteinPam Taub
May 22, 2018·Pediatric Blood & Cancer·Tarek AlsaiedMichael D Taylor
May 13, 2021·PloS One·Jonas Alves de Araujo JuniorMeliza Goi Roscani
Aug 2, 2021·European Journal of Preventive Cardiology·Benjamin J R BuckleyGregory Y H Lip
Aug 17, 2021·Current Opinion in Cardiology·Elizabeth EpsteinPam R Taub

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