Exercise Training in Patients With Non-Small Cell Lung Cancer During In-Hospital Chemotherapy Treatment: A RANDOMIZED CONTROLLED TRIAL

Journal of Cardiopulmonary Rehabilitation and Prevention
Anna RutkowskaRichard Casaburi

Abstract

The aim of this study was to perform a randomized trial to assess the impact of exercise training in patients with non-small cell lung cancer during chemotherapy on several outcomes in comparison to a control group (CG). The exercise training group (ETG) consisted of 20 patients and the CG consisted of 10 patients. In the ETG, a 4-wk in-hospital exercise training program was performed in 2-wk cycles interspersed with consecutive rounds of chemotherapy with cytostatic drugs. The exercise training program was individualized and included warm-up, respiratory muscle exercise, training on a cycle ergometer or treadmill, and Nordic walking. CG participants were assessed before and after 6 wk of chemotherapy alone. Comparing pre- and post-intervention values, the ETG demonstrated an increase in 6-min walk distance (486 ± 92 vs 531 ± 103 m, P = .01). In a battery of physical performance tests: Up and Go Test (6.3 ± 1.0 vs 6.0 ± 1.1 sec, P = .01); chair stand (13.3 ± 2.8 vs 14.3 ± 3.4 repetitions, P = .001); and arm curl (18.4 ± 3.1 vs 20.4 ± 3.5 repetitions, P = .001) all improved significantly. Spirometry values also improved: FEV1 % predicted (76 ± 16 vs 84 ± 15, P = .01), FVC % predicted (87 ± 14 vs 95 ± 13, P = .01), and FEV1/FVC (...Continue Reading

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Citations

Jan 7, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Junga Lee
Feb 23, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David HuiMargaret L Campbell
May 9, 2021·Journal of Aging and Physical Activity·Mary E MedyskyKerri M Winters-Stone
Jul 21, 2021·Seminars in Oncology Nursing·Lauren C CapozziS Nicole Culos-Reed
Aug 28, 2021·International Journal of Molecular Sciences·Hiroki NishikawaKazuhide Higuchi

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