Exercise training increases size of hippocampus and improves memory

Proceedings of the National Academy of Sciences of the United States of America
Kirk I EricksonArthur F Kramer

Abstract

The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. Hippocampal and medial temporal lobe volumes are larger in higher-fit adults, and physical activity training increases hippocampal perfusion, but the extent to which aerobic exercise training can modify hippocampal volume in late adulthood remains unknown. Here we show, in a randomized controlled trial with 120 older adults, that aerobic exercise training increases the size of the anterior hippocampus, leading to improvements in spatial memory. Exercise training increased hippocampal volume by 2%, effectively reversing age-related loss in volume by 1 to 2 y. We also demonstrate that increased hippocampal volume is associated with greater serum levels of BDNF, a mediator of neurogenesis in the dentate gyrus. Hippocampal volume declined in the control group, but higher preintervention fitness partially attenuated the decline, suggesting that fitness protects against volume loss. Caudate nucleus and thalamus volumes were unaffected by the intervention. These theoretically important findings indicate that aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood, which is accompanied by improved...Continue Reading

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J E BlackW T Greenough
Feb 1, 1987·Neurology·G SchrothK Voigt
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·M B MoserR G Morris
Jan 12, 1995·Nature·S A NeeperC Cotman
Aug 10, 1999·Nature·A F KramerA Colcombe
Sep 19, 2000·Medicine and Science in Sports and Exercise·S J StrathB E Ainsworth
Dec 1, 2001·Science·R LeeB L Hempstead
Jun 28, 2002·Trends in Neurosciences·Carl W Cotman, Nicole C Berchtold
Mar 29, 2003·Psychological Science·Stanley Colcombe, Arthur F Kramer
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stanley J ColcombeSteriani Elavsky
Mar 30, 2004·Journal of Neuroscience Research·Melissa M HolmesGerd Kempermann
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Nov 19, 2004·The European Journal of Neuroscience·Shoshanna VaynmanFernando Gomez-Pinilla
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henriette van PraagFred H Gage
Dec 15, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stanley J ColcombeArthur F Kramer
Mar 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ana C PereiraScott A Small
Dec 21, 2007·Nature Reviews. Neuroscience·Charles H HillmanArthur F Kramer
Jan 6, 2009·Hippocampus·Kirk I EricksonArthur F Kramer
Aug 12, 2009·Experimental Physiology·Peter RasmussenHenriette Pilegaard
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Robyn A HoneaJeffrey M Burns
Oct 23, 2009·Neurology·C A RajiJ T Becker
Dec 23, 2009·Brain Research·Susie HeoArthur F Kramer
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·David J CreerTimothy J Bussey
Mar 30, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Caterina RosanoHoward Aizenstein
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kirk I EricksonArthur F Kramer
Oct 12, 2010·Brain : a Journal of Neurology·Clifford R JackUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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Citations

Jul 21, 2011·Archives of Internal Medicine·Marie-Noël VercambreJae H Kang
Jan 27, 2012·Zeitschrift für Gerontologie und Geriatrie·M D DenkingerA Lukas
Jul 23, 2013·European Archives of Psychiatry and Clinical Neuroscience·Berend MalchowPeter Falkai
Sep 20, 2012·European Journal of Applied Physiology·David A RaichlenGregory L Gerdeman
Jul 5, 2012·Brain Structure & Function·Nasim MalekiDavid Borsook
Feb 16, 2013·Prevention Science : the Official Journal of the Society for Prevention Research·Sean P MullenEdward McAuley
Aug 19, 2011·Neurotoxicity Research·Trevor Archer, Richard M Kostrzewa
Jun 7, 2013·Aging Clinical and Experimental Research·Jolanta Dorszewska
Jan 8, 2013·Appetite·Heather Francis, Richard Stevenson
Aug 19, 2014·Computer Vision and Image Understanding : CVIU·Jing XieOwen Carmichael
Jun 22, 2012·The Proceedings of the Nutrition Society·M J Dauncey
Feb 22, 2013·International Psychogeriatrics·Gary W SmallFernando Torres-Gil
Jun 29, 2013·International Psychogeriatrics·Alexander KurzNicola T Lautenschlager
Nov 2, 2011·Journal of the International Neuropsychological Society : JINS·Laura ChaddockArthur F Kramer
Nov 2, 2011·Journal of the International Neuropsychological Society : JINS·Ruchika Shaurya PrakashAaron Boster
Nov 2, 2011·Journal of the International Neuropsychological Society : JINS·Michelle C Carlson
Apr 27, 2012·Nature Neuroscience·Richard J Davidson, Bruce S McEwen
Jul 25, 2012·Nature Reviews. Neurology·Robert W Motl, Lara A Pilutti
Nov 22, 2012·Translational Psychiatry·B M BrownUNKNOWN AIBL research group
Apr 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Robert F CoenRoseAnne Kenny
Dec 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Vegard SkirbekkDaniela Weber
Oct 1, 2011·Research Quarterly for Exercise and Sport·Beth A ParkerGodfrey D Pearlson
Nov 10, 2011·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Thomas M LaudateAlice Cronin-Golomb
Dec 6, 2011·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Vadim YerokhinMollie Shulan
Feb 9, 2012·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Eduard Kraft
Jul 10, 2012·Cerebral Cortex·Peter J GianarosTimothy D Verstynen
Apr 5, 2012·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Sean P MullenThomas R Prohaska
Nov 14, 2013·The Journal of Craniofacial Surgery·Hua ZhongYouqiong Li
Jun 20, 2012·Alzheimer Disease and Associated Disorders·Gustavo C RománHoward Fillit
Nov 23, 2012·Proceedings. Biological Sciences·David A Raichlen, John D Polk
Sep 1, 2011·Learning & Memory·Tali KobiloHenriette van Praag
Apr 30, 2011·Journal of Applied Physiology·Michelle W VossArthur F Kramer
Jan 11, 2013·Journal of Aging Research·Regina L LeckieKirk I Erickson
May 17, 2012·Dementia and Geriatric Cognitive Disorders Extra·Astrid M HooghiemstraErik J A Scherder
Dec 20, 2012·Journal of Cognitive Neuroscience·Megan M Herting, Bonnie J Nagel
Oct 16, 2012·American Journal of Respiratory and Critical Care Medicine·Ramona O HopkinsDale Needham

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