Exercise training-induced bradycardia: evidence for enhanced parasympathetic regulation without changes in intrinsic sinoatrial node function

Journal of Applied Physiology
G E BillmanVadim V Fedorov

Abstract

The mechanisms responsible for exercise-induced reductions in baseline heart rate (HR), known as training bradycardia, remain controversial. Therefore, changes in cardiac autonomic regulation and intrinsic sinoatrial nodal (SAN) rate were evaluated using dogs randomly assigned to either a 10- to 12-wk exercise training (Ex, n = 15) or an equivalent sedentary period (Sed, n = 10). Intrinsic HR was revealed by combined autonomic nervous system (ANS) blockade (propranolol + atropine, iv) before and after completion of the study. At the end of the study, SAN function was further evaluated by examining the SAN recovery time (SNRT) following rapid atrial pacing and the response to adenosine in anesthetized animals. As expected, both the response to submaximal exercise and baseline HR significantly (P < 0.01) decreased, and heart rate variability (HRV; e.g., high-frequency R-R interval variability) significantly (P < 0.01) increased in the Ex group but did not change in the Sed group. Atropine also induced significantly (P < 0.01) greater reductions in HRV in the Ex group compared with the Sed group; propranolol elicited similar HR and HRV changes in both groups. In contrast, neither intrinsic HR (Ex before, 141.2 ± 6.7; Ex after, 146...Continue Reading

References

Jun 1, 1992·The American Journal of Physiology·J R Halliwill, G E Billman
Mar 1, 1990·The American Journal of Physiology·G E Billman, J P Dujardin
Nov 1, 1989·The American Journal of Physiology·Y T ShenS F Vatner
Nov 1, 1989·Journal of Pharmacological Methods·A Van de WaterR S Reneman
Apr 1, 1989·Journal of Applied Physiology·D R Seals, P B Chase
Feb 1, 1989·Medicine and Science in Sports and Exercise·M L SmithP B Raven
Jan 1, 1982·European Journal of Applied Physiology and Occupational Physiology·E NylanderA Kilbom
Jun 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A OrdwayD R Wekstein
Jun 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P G KatonaA Guz
Oct 1, 1981·The American Journal of Physiology·J A Hirsch, B Bishop
Jul 1, 1980·Acta Physiologica Scandinavica·S F LewisN H Areskog
Dec 1, 1996·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J GregoireR L Hughson
May 20, 1998·Medicine and Science in Sports and Exercise·D BonaduceF Marciano
Mar 15, 2001·Journal of Applied Physiology·K N JewR L Moore
Mar 19, 2002·Journal of the American College of Cardiology·Ricardo SteinJorge P Ribeiro
Dec 13, 2002·Sports Medicine·James B CarterAndrew P Blaber
Jan 11, 2003·The American Journal of Cardiology·Terence KavanaghMagdi Yacoub
Jan 20, 2004·Journal of Applied Physiology·K De AngelisM C Irigoyen
Jun 5, 2004·Medicine and Science in Sports and Exercise·Julie BarbierFrançois Carré
Jul 6, 2004·Autonomic Neuroscience : Basic & Clinical·Adrienne S ScottHélène Perrault
Jun 21, 2005·Pharmacology & Therapeutics·Mirko BaruscottiDario Difrancesco
Jan 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·George E BillmanRuth A Altschuld
Oct 20, 2006·International Journal of Cardiology·Luciano BernardiGiorgio Finardi
Mar 8, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tobias OpthofMichiel J Janse
May 22, 2007·Pharmacology & Therapeutics·Angelina Zanesco, Edson Antunes
Aug 28, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Bethany J HolycrossGeorge E Billman
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·George E Billman
Nov 26, 2010·Biochimica Et Biophysica Acta·John P HeadrickLuke J Haseler
Jun 11, 2011·The American Journal of Cardiology·Matthias WilhelmHugo Saner
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Kaushik P Patel, Hong Zheng
Dec 7, 2011·Frontiers in Physiology·George E Billman
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Thomas O'Hara, Yoram Rudy
Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Vadim V FedorovRoger Chang

❮ Previous
Next ❯

Citations

Apr 28, 2016·Pacing and Clinical Electrophysiology : PACE·Antonis S Manolis, Antonis A Manolis
Apr 27, 2016·The Journal of Physiology·Kalyanam ShivkumarDouglas P Zipes
Mar 14, 2017·Clinical and Experimental Hypertension : CHE·Jitanan LaosiripisanHirofumi Tanaka
Aug 18, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P R LopesG R Pedrino
Mar 28, 2017·Pacing and Clinical Electrophysiology : PACE·Akihiro SunagaMasaaki Uematsu
Jan 13, 2018·Nature Reviews. Neuroscience·Mark P MattsonAiwu Cheng
Jun 11, 2019·Frontiers in Physiology·Christoph SchneiderAlexander Ferrauti
Jul 8, 2017·Journal of Applied Physiology·Mark R BoyettAlicia D'Souza
Jul 8, 2017·Journal of Applied Physiology·Mark R BoyettAlicia D'Souza
Sep 28, 2017·Journal of Applied Physiology·Darragh FlanneryFeng He
Aug 18, 2018·Nature Reviews. Cardiology·Carmen Fiuza-LucesAlejandro Lucia
Sep 28, 2017·Journal of Applied Physiology·George E Billman
Jul 8, 2017·Journal of Applied Physiology·George E Billman
Feb 11, 2020·Frontiers in Physiology·N Sydney MoïseRomain Pariaut
Aug 17, 2019·International Journal of Molecular Sciences·Ayko BreslerKerstin Troidl
Jun 27, 2019·The Journal of Sports Medicine and Physical Fitness·Veljko ProkicVladimir Zivkovic
Nov 18, 2020·Circulation. Arrhythmia and Electrophysiology·Jose Carlos Pachon-MThiago G Osorio
Apr 14, 2021·The Journal of General Physiology·Farbod FazlollahiPaul M L Janssen
Jul 20, 2021·Frontiers in Physiology·Ido Weiser-BitounYael Yaniv
Sep 4, 2021·Cardiovascular Research·Fabian Sanchis-GomarSteven N Blair
Dec 28, 2021·Applied Psychophysiology and Biofeedback·Vicente Javier Clemente-SuárezJosé Francisco Tornero-Aguilera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.