Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients

American Journal of Physiology. Heart and Circulatory Physiology
Raphaela V GroehsC E Negrão

Abstract

Arterial baroreflex control of muscle sympathetic nerve activity (ABRMSNA) is impaired in chronic systolic heart failure (CHF). The purpose of the study was to test the hypothesis that exercise training would improve the gain and reduce the time delay of ABRMSNA in CHF patients. Twenty-six CHF patients, New York Heart Association Functional Class II-III, EF ≤ 40%, peak V̇o2 ≤ 20 ml·kg(-1)·min(-1) were divided into two groups: untrained (UT, n = 13, 57 ± 3 years) and exercise trained (ET, n = 13, 49 ± 3 years). Muscle sympathetic nerve activity (MSNA) was directly recorded by microneurography technique. Arterial pressure was measured on a beat-to-beat basis. Time series of MSNA and systolic arterial pressure were analyzed by autoregressive spectral analysis. The gain and time delay of ABRMSNA was obtained by bivariate autoregressive analysis. Exercise training was performed on a cycle ergometer at moderate intensity, three 60-min sessions per week for 16 wk. Baseline MSNA, gain and time delay of ABRMSNA, and low frequency of MSNA (LFMSNA) to high-frequency ratio (HFMSNA) (LFMSNA/HFMSNA) were similar between groups. ET significantly decreased MSNA. MSNA was unchanged in the UT patients. The gain and time delay of ABRMSNA were unc...Continue Reading

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Citations

Oct 22, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Zhengtang Qi, Shuzhe Ding
Apr 27, 2016·The Journal of Physiology·Kalyanam ShivkumarDouglas P Zipes
Aug 21, 2016·Annals of Physical and Rehabilitation Medicine·Florent BesnierThibaut Guiraud
Sep 19, 2016·JACC. Cardiovascular Interventions·Can ÖztürkChristoph Hammerstingl
Dec 14, 2016·European Journal of Preventive Cardiology·Ligia M Antunes-CorreaCarlos E Negrao
Dec 14, 2017·ESC Heart Failure·Gaia CattadoriClaudio Anzà
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Jun 28, 2018·Sleep & Breathing = Schlaf & Atmung·Edgar Toschi-DiasMaria Urbana P B Rondon
Sep 3, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Adriana Oliveira SarmentoBarbara M Ianni
Aug 5, 2017·ESC Heart Failure·Ana Luiza C SayeghMaria Janieire de Nazaré Nunes Alves
Sep 11, 2021·International Journal of Cardiology·Guilherme Veiga GuimarãesEdimar Alcides Bocchi

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