Exercise training prevents the perivascular adipose tissue-induced aortic dysfunction with metabolic syndrome

Redox Biology
Evan DeVallancePaul D Chantler

Abstract

The aim of the study was to determine the effects of exercise training on improving the thoracic perivascular adipose tissue (tPVAT) phenotype (inflammation, oxidative stress, and proteasome function) in metabolic syndrome and its subsequent actions on aortic function. Lean and obese (model of metabolic syndrome) Zucker rats (n=8/group) underwent 8-weeks of control conditions or treadmill exercise (70% of max speed, 1 h/day, 5 days/week). At the end of the intervention, the tPVAT was removed and conditioned media was made. The cleaned aorta was attached to a force transducer to assess endothelium-dependent and independent dilation in the presence or absence of tPVAT-conditioned media. tPVAT gene expression, inflammatory /oxidative phenotype, and proteasome function were assessed. The main findings were that Ex induced: (1) a beige-like, anti-inflammatory tPVAT phenotype; (2) a greater abundance of •NO in tPVAT; (3) a reduction in tPVAT oxidant production; and (4) an improved tPVAT proteasome function. Regarding aortic function, endothelium-dependent dilation was greater in exercised lean and obese groups vs. controls (p < 0.05). Lean control tPVAT improved aortic relaxation, whereas obese control tPVAT decreased aortic relaxati...Continue Reading

Citations

Jun 13, 2020·Diabetologia·John P Thyfault, Audrey Bergouignan
Oct 22, 2020·International Journal of Molecular Sciences·Sandra Feijóo-BandínFrancisca Lago
Jul 3, 2020·Current Pharmaceutical Design·Jamaira A VictorioAna P Davel
Mar 10, 2021·Cardiovascular Drugs and Therapy·Sophie N SaxtonAnthony M Heagerty

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BETA
PCR
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PASS
ImageJ
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