Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice

Physiological Reports
Rujie QinMasaki Ieda

Abstract

Exercise can improve morbidity and mortality in heart failure patients; however, the underlying mechanisms remain to be fully investigated. Thus, we investigated the effects of exercise on cardiac function and ventricular arrhythmias in myocardial infarction (MI) induced heart failure mice. Wild-type male mice underwent sham-operation or permanent left coronary artery ligation to induce MI. MI mice were divided into a sedentary (MI-Sed) and two intervention groups: MI-Ex (underwent 6-week treadmill exercise training) and MI-βb (oral bisoprolol treatment (1 mg/kg/d) without exercise). Cardiac function and structure were assessed by echocardiography and histology. Exercise capacity and cardiopulmonary function was accepted as oxygen consumption at peak exercise (peak VO2 ). Autonomic nervous system function and the incidence of spontaneous ventricular arrhythmia were evaluated via telemetry recording. mRNA and protein expressions in the left ventricle (LV) were investigated by real-time PCR and Western blotting. There were no differences in survival rate, MI size, cardiac function and structure, while exercise training improved peak VO2 . Compared with MI-Sed, MI-Ex, and MI-βb showed decreased sympathetic tone and lower incidence...Continue Reading

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Citations

Jul 28, 2019·Cardiovascular Research·Sirisha M CheedipudiAli J Marian
Aug 19, 2020·Nature Metabolism·Jose B N MoreiraUlrik Wisløff
Sep 4, 2021·Cardiovascular Research·Fabian Sanchis-GomarSteven N Blair
Sep 6, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Xiao LiuThomas H Everett
Sep 25, 2021·Physiological Reports·Mani SadrediniMathis K Stokke

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