Abstract
This study investigated whether exercise training had a beneficial effect on the decreased mitogen response and improved a decreased expression of glucose transporter 1 (GLUT-1) in splenocytes from obese Zucker rats. Experimental groups were lean and sedentary and exercise-trained obese Zucker rats. Exercise training, running on a motor-driven treadmill for 5 days/wk for 40 wk, did not induce a significant decrease in body weight in obese Zucker rats. The plasma insulin concentration, showing a significant increase compared with lean Zucker rats, was unaffected by exercise training. However, the plasma triglyceride concentration in obese Zucker rats was significantly depressed by exercise training, whereas it was still higher than that in lean Zucker rats. In addition, natural killer cell activity and concanavalin A-induced mitogenesis of splenic lymphocytes of obese Zucker rats were significantly restored. In these splenic lymphocytes, glucose uptake was significantly lower compared with that in lean Zucker rats, which was also improved by exercise training. Although the expression of GLUT-1, the major glucose transporter in immune cells, was depressed in splenic lymphocytes of obese Zucker rats, exercise training induced a si...Continue Reading
References
Jan 1, 1979·International Archives of Allergy and Applied Immunology·C J MeadeJ Mertin
Jul 1, 1976·Diabetes·M G Pallavicini, W K Nichols
Sep 1, 1992·Diabetes·L J GoodyearE S Horton
Oct 1, 1992·The Journal of Clinical Investigation·P A KingE S Horton
Dec 1, 1990·International Journal of Sports Medicine·D C NiemanK Arabatzis
Jan 1, 1989·Advances in Immunology·M L Thoman, W O Weigle
Jan 1, 1987·International Archives of Allergy and Applied Immunology·A M AttallahG B Helfrich
Jan 1, 1987·Prostaglandins, Leukotrienes, and Medicine· Pham Huu ChanhR Moutier
Mar 1, 1987·Diabetes·G van de WerveB Jeanrenaud
Sep 6, 1985·Science·M MuecklerH F Lodish
Dec 1, 1985·Annals of Internal Medicine·L Garfinkel
Dec 1, 1985·Annals of Internal Medicine·T B Van Itallie
Dec 1, 1985·The Journal of Nutrition·L A Marshall, P V Johnston
Oct 1, 1969·Metabolism: Clinical and Experimental·W S Barry, G A Bray
Jul 1, 1967·Annals of Internal Medicine·W B KannelP M McNamara
Jan 1, 1984·Mechanisms of Ageing and Development·J A Bash, D Vogel
Jan 1, 1983·Progress in Lipid Research·M I Gurr
Jul 1, 1995·Medicine and Science in Sports and Exercise·D C NiemanS L Nehlsen-Cannarella
Jan 1, 1995·Journal of Applied Physiology·J L HallW C Stanley
Oct 1, 1994·Journal of Endocrinological Investigation·G GiacchettiR De Pirro
Sep 1, 1994·Journal of Gerontology·M G HayekJ B Blumberg
Nov 1, 1993·Cellular Signalling·N W MerrallG W Gould
Jul 1, 1993·Medicine and Science in Sports and Exercise·D C NiemanS L Nehlsen-Cannarella
Mar 1, 1993·Journal of Applied Physiology·J G Cannon
Mar 1, 1984·Immunology Today·K N Traill, G Wick
Citations
May 17, 2008·Obesity·Megan R RuthCatherine J Field
Apr 16, 2008·Journal of Cellular and Molecular Medicine·Jiejie HaoJiankang Liu
Apr 24, 2007·The Journal of Nutrition·Alexia G SmithMelinda A Beck
Mar 25, 2006·Endocrine Reviews·Joaquín López-SorianoJosep M Argilés
Dec 3, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M R RuthC J Field
Oct 23, 2002·Journal of Applied Physiology·Gwendolyn F ElphickMonika Fleshner
Sep 25, 2004·Journal of Cellular Physiology·Marie-Céline BlancJean-Pascal De Bandt
Apr 10, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Paweł PiatkiewiczJan Tatoń
Nov 13, 2009·Nutrition Reviews·Rubhana Raqib, Alejandro Cravioto
Apr 27, 2002·Annals of the New York Academy of Sciences·Jeffrey A WoodsK Todd Keylock
Dec 21, 2011·Integrative Zoology·Deli XuDehua Wang
Jan 8, 2015·Journal of Exercise Nutrition & Biochemistry·Hee Geun ParkWang Lok Lee
Feb 17, 2017·Experimental Physiology·Alina GheorgheMónica De la Fuente
Feb 1, 2010·Nutrients·Megan R RuthCatherine J Field
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K J O'ByrneA L Harris