Exercise training restores decreased cellular immune functions in obese Zucker rats

Journal of Applied Physiology
S MoriguchiE Shimizu

Abstract

This study investigated whether exercise training had a beneficial effect on the decreased mitogen response and improved a decreased expression of glucose transporter 1 (GLUT-1) in splenocytes from obese Zucker rats. Experimental groups were lean and sedentary and exercise-trained obese Zucker rats. Exercise training, running on a motor-driven treadmill for 5 days/wk for 40 wk, did not induce a significant decrease in body weight in obese Zucker rats. The plasma insulin concentration, showing a significant increase compared with lean Zucker rats, was unaffected by exercise training. However, the plasma triglyceride concentration in obese Zucker rats was significantly depressed by exercise training, whereas it was still higher than that in lean Zucker rats. In addition, natural killer cell activity and concanavalin A-induced mitogenesis of splenic lymphocytes of obese Zucker rats were significantly restored. In these splenic lymphocytes, glucose uptake was significantly lower compared with that in lean Zucker rats, which was also improved by exercise training. Although the expression of GLUT-1, the major glucose transporter in immune cells, was depressed in splenic lymphocytes of obese Zucker rats, exercise training induced a si...Continue Reading

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Citations

Apr 16, 2008·Journal of Cellular and Molecular Medicine·Jiejie HaoJiankang Liu
Dec 3, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M R RuthC J Field
Oct 23, 2002·Journal of Applied Physiology·Gwendolyn F ElphickMonika Fleshner
Sep 25, 2004·Journal of Cellular Physiology·Marie-Céline BlancJean-Pascal De Bandt
Apr 10, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Paweł PiatkiewiczJan Tatoń
Nov 13, 2009·Nutrition Reviews·Rubhana Raqib, Alejandro Cravioto
Apr 27, 2002·Annals of the New York Academy of Sciences·Jeffrey A WoodsK Todd Keylock
Feb 17, 2017·Experimental Physiology·Alina GheorgheMónica De la Fuente
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K J O'ByrneA L Harris

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