Exercise without dietary changes alleviates nonalcoholic fatty liver disease without weight loss benefits

Lipids in Health and Disease
Duck-Pil OkJu Yong Bae

Abstract

This study aimed to analyze the effect of exercise and/or dietary change on improvement of non-alcoholic fatty liver disease (NAFLD) in chronic high-fat diet (HFD)-induced obese mice. Forty male C57BL/6 (8 weeks old) mice were divided into normal diet (CO, n = 8) and high-fat diet (HF, n = 32) groups. The HF group was fed with 60% fat chow for 16 weeks to induce obesity. After the obesity induction period, the HF group was subdivided into HFD + sedentary (n = 8), HFD + training (HFT, n = 8), dietary change to normal-diet + sedentary (HFND, n = 8), and dietary change to normal-diet + training (HFNDT, n = 8) groups, and the mice in the training groups underwent treadmill training for 8 weeks, 5 times per week, 40 min per day. A 24-week HFD induced increase of cannabinoid-1 receptor (CB1), fatty acid synthase (FAS), and AMP-activated protein kinase (AMPK) protein expressions (p < 0.05) and decrease of p-AMPK and carnitine palmitoyltransferase1 (CPT1) protein expressions (P < 0.05), resulting in increased liver fat accumulation. Treatment of exercise with dietary change and dietary change alone decreased CB1 and AMPK protein expressions with increased p-AMPK and CPT1 protein expressions (P < 0.05), leading to decreased body weight ...Continue Reading

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Citations

Oct 18, 2020·International Journal of Molecular Sciences·Jonatan DassonvalleRodrigo Troncoso
Nov 14, 2020·International Journal of Environmental Research and Public Health·Ju Yong Bae
Dec 4, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wenqi YangLiangming Li
May 27, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tianyi WangLi Fu

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Methods Mentioned

BETA
protein assay
electrophoresis

Software Mentioned

Statistical Package for Social Sciences

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