Exercising your fat (metabolism) into shape: a muscle-centred view.

Diabetologia
Anne GemminkMatthijs K C Hesselink

Abstract

Fatty acids are an important energy source during exercise. Training status and substrate availability are determinants of the relative and absolute contribution of fatty acids and glucose to total energy expenditure. Endurance-trained athletes have a high oxidative capacity, while, in insulin-resistant individuals, fat oxidation is compromised. Fatty acids that are oxidised during exercise originate from the circulation (white adipose tissue lipolysis), as well as from lipolysis of intramyocellular lipid droplets. Moreover, hepatic fat may contribute to fat oxidation during exercise. Nowadays, it is clear that myocellular lipid droplets are dynamic organelles and that number, size, subcellular distribution, lipid droplet coat proteins and mitochondrial tethering of lipid droplets are determinants of fat oxidation during exercise. This review summarises recent insights into exercise-mediated changes in lipid metabolism and insulin sensitivity in relation to lipid droplet characteristics in human liver and muscle. Graphical abstract.

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Citations

Sep 26, 2020·International Journal of Molecular Sciences·Amanda J GendersDavid J Bishop
Aug 25, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Sion A ParryLeanne Hodson
Jan 22, 2021·Physiological Reports·Nynke van PolanenMatthijs K C Hesselink
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Aug 17, 2021·American Journal of Physiology. Endocrinology and Metabolism·Sabine DaemenMatthijs K C Hesselink

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Methods Mentioned

BETA
biopsies

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