Exfoliative respiratory cytology in the diagnosis of leukemias and lymphomas in the lung

Diagnostic Cytopathology
R H BardalesM W Stanley

Abstract

Leukemias and lymphomas involving the lung were diagnosed by means of exfoliative cytology in 31 specimens from 20 patients. Initial diagnostic categorizations included 29 specimens "positive for malignancy," including two thought to represent "carcinoma vs. lymphoma," and two considered suspicious for lymphoma. Previous diagnoses of lymphoma (13 patients) and acute myelogenous leukemia (AML) (2 patients) were available. In 5 additional patients, exfoliative respiratory cytology yielded the first diagnosis of hematopoietic malignancy. Cytologic diagnosis included nine large-cell and six small-cell non-Hodgkin's lymphomas (NHL), three Hodgkin's lymphomas (HD), and two AML. Key cytologic features included markedly pleomorphic and monomorphic cell populations in HD and NHL, respectively, as well as lack of tumor cell cohesion and necrosis in all cases. Cytologically, acute leukemia may be difficult to differentiate from large-cell NHL, and small-cell NHL from reactive/benign small lymphocytes. Blood, scant cellularity, crush artifacts, and apparent molding may affect diagnostic accuracy. Immunocytochemistry in cell block sections of sputa and washings is useful in the diagnostic workup in selected cases. Although involvement of th...Continue Reading

References

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Citations

Jul 9, 2010·Revue des maladies respiratoires·Y UzunhanA Bergeron
Mar 15, 2016·Diagnostic Cytopathology·Jia QinConstantine A Axiotis
Sep 26, 2012·Diagnostic Cytopathology·Leah A DvorakStefan E Pambuccian

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