Exhaled and arterial levels of endothelin-1 are increased and correlate with pulmonary systolic pressure in COPD with pulmonary hypertension

BMC Pulmonary Medicine
Pierluigi CarratuOnofrio Resta

Abstract

Endothelin-1 (ET-1) and Nitric Oxide (NO) are crucial mediators for establishing pulmonary artery hypertension (PAH). We tested the hypothesis that their imbalance might also occur in COPD patients with PAH. The aims of the study were to measure exhaled breath condensate (EBC) and circulating levels of ET-1, as well as exhaled NO (FENO) levels by, respectively, a specific enzyme immunoassay kit, and by chemiluminescence analysis in 3 groups of subjects: COPD with PAH (12), COPD only (36), and healthy individuals (15). In order to evaluate pulmonary-artery systolic pressure (PaPs), all COPD patients underwent Echo-Doppler assessment. Significantly increased exhaled and circulating levels of ET-1 were found in COPD with PAH compared to both COPD (p < 0.0001) only, and healthy controls (p < 0.0001). In COPD with PAH, linear regression analysis showed good correlation between ET-1 in EBC and PaPs (r = 0.621; p = 0.031), and between arterial levels of ET-1 and PaPs (r = 0.648; p = 0.022), while arterial levels of ET-1 inversely correlated with FEV1%, (r = -0.59, p = 0.043), and PaPs negatively correlated to PaO2 (r = -0.618; p = 0.032). Significantly reduced levels of FENO were found in COPD associated with PAH, compared to COPD onl...Continue Reading

References

Jul 9, 1992·The New England Journal of Medicine·B W ChristmanJ E Loyd
May 30, 1991·The New England Journal of Medicine·A T Dinh-XuanJ Wallwork
May 1, 1973·The Medical Clinics of North America·J M Bishop
Mar 1, 1994·American Journal of Respiratory Cell and Molecular Biology·M K GlassbergD Puett
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Jun 1, 1995·Journal of Clinical Pathology·C FerriA Santucci
Jan 1, 1994·Respiration; International Review of Thoracic Diseases·M SofiaL Carratù
Jun 17, 1993·The New England Journal of Medicine·A GiaidD J Stewart
Sep 21, 1996·BMJ : British Medical Journal·J M Bland, D G Altman
Sep 8, 1998·Respiration; International Review of Thoracic Diseases·G Celik, G Karabiyikoğlu
Aug 13, 1999·The European Respiratory Journal·G W ChalmersN C Thomson
Mar 4, 2000·The European Respiratory Journal·M LévyA T Dinh-Xuan
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·R KesslerM Oswald-Mammosser
Dec 12, 2001·Critical Care : the Official Journal of the Critical Care Forum·R Naeije, J A Barberà
Jan 31, 2002·American Journal of Respiratory and Critical Care Medicine·Neil DavieJohn Wharton
May 10, 2002·The European Respiratory Journal·S SantosJ A Barberà
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Steven M ScharfUNKNOWN National Emphysema Treatment Trial (NETT) Group
May 13, 2003·Respiration; International Review of Thoracic Diseases·G E CarpagnanoP J Barnes
Feb 1, 1952·Journal of Clinical Pathology·W S C SYMMERS
Jul 10, 2004·American Journal of Respiratory Cell and Molecular Biology·Joanne L WrightAndrew Churg
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Reda E GirgisJ T Sylvester
Mar 25, 2006·American Journal of Respiratory and Critical Care Medicine·Peter J BarnesMarina Saetta
Mar 28, 2006·Proceedings of the American Thoracic Society·Philip E SilkoffUNKNOWN HOC Subcommittee of the Assembly on Allergy, Immunology, and Inflammation
Apr 9, 2008·Respiratory Medicine·Z ZietkowskiA Bodzenta-Lukaszyk

❮ Previous
Next ❯

Citations

Oct 6, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tomonobu KoizumiKeishi Kubo
Aug 8, 2012·Respiration; International Review of Thoracic Diseases·Corey E VentetuoloDavid J Lederer
Apr 17, 2012·American Journal of Respiratory and Critical Care Medicine·Shamsah Kazani, Elliot Israel
Nov 3, 2009·Annals of Thoracic Medicine·Abdullah A Abba
Sep 1, 2009·Expert Opinion on Medical Diagnostics·Mauro ManiscalcoMatteo Sofia
Jul 17, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Meigui ZhouYixiang Duan
Apr 6, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·E C OelsnerR G Barr
Jun 25, 2015·TheScientificWorldJournal·Efstathia M KonstantinidiPanagiotis K Behrakis
Jul 16, 2013·International Journal of Cardiology·Charlotte U AndersenUlf Simonsen
Jul 10, 2014·Pulmonary Circulation·Graziela S ReisPaulo Roberto B Evora
Aug 8, 2015·The European Respiratory Journal·Rosa FanerAlvar Agusti
Mar 8, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Priscilla HennoDominique Israël-Biet
Dec 22, 2019·The European Respiratory Journal·Claire BouvardChristelle Guibert
Aug 3, 2012·Journal of Breath Research·Geoffrey WarwickDeborah H Yates
Nov 29, 2008·Clinical Science·Tamera J Corte, Stephen J Wort
Sep 20, 2015·Sleep & Breathing = Schlaf & Atmung·Pierluigi CarratùOnofrio Resta
Jan 1, 2013·International Journal of Chronic Diseases·Mann Ying Lim, Paul S Thomas
Sep 19, 2018·BioMed Research International·Giovanna Elisiana CarpagnanoMario Malerba
Jan 14, 2021·Biomedicines·Kondababu KurakulaMarie-José Goumans

❮ Previous
Next ❯

Software Mentioned

StatView
KaleidaGraph
Synergy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.