Exhaled and non-exhaled non-invasive markers for assessment of respiratory inflammation in patients with stable COPD and healthy smokers

Journal of Breath Research
Giuseppe SantiniP Montuschi

Abstract

We aimed at comparing exhaled and non-exhaled non-invasive markers of respiratory inflammation in patients with chronic obstructive pulmonary disease (COPD) and healthy subjects and define their relationships with smoking habit. Forty-eight patients with stable COPD who were ex-smokers, 17 patients with stable COPD who were current smokers, 12 healthy current smokers and 12 healthy ex-smokers were included in a cross-sectional, observational study. Inflammatory outcomes, including prostaglandin (PG) E2 and 15-F2t-isoprostane (15-F2t-IsoP) concentrations in exhaled breath condensate (EBC) and sputum supernatants, fraction of exhaled nitric oxide (FENO) and sputum cell counts, and functional (spirometry) outcomes were measured. Sputum PGE2 was elevated in both groups of smokers compared with ex-smoker counterpart (COPD: P  <  0.02; healthy subjects: P  <  0.03), whereas EBC PGE2 was elevated in current (P  =  0.0065) and ex-smokers with COPD (P  =  0.0029) versus healthy ex-smokers. EBC 15-F2t-IsoP, a marker of oxidative stress, was increased in current and ex-smokers with COPD (P  <  0.0001 for both) compared with healthy ex-smokers, whereas urinary 15-F2t-IsoP was elevated in both smoker groups (COPD: P  <  0.01; healthy subjec...Continue Reading

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Citations

Apr 10, 2017·Redox Biology·Thomas J van 't ErveRonald P Mason
Sep 3, 2016·Archives of Toxicology·Joachim D Pleil
Aug 5, 2017·Journal of Breath Research·Barbara RindlisbacherManuela Funke-Chambour
Dec 1, 2017·Journal of Breath Research·Maud LacombeVirginie Brun
Feb 1, 2017·Journal of Breath Research·L BlanchetF J van Schooten
Apr 11, 2019·Journal of Breath Research·Altug KocYasemin Basbinar
Jun 3, 2020·International Journal of Molecular Sciences·Yara ShomanIrina Guseva Canu
Sep 18, 2020·Biomarkers in Medicine·Somayeh KazeminasabMaryam Khoubnasabjafari
Mar 27, 2019·Oxidative Medicine and Cellular Longevity·Ana Paula SierraRodolfo Paula Vieira
Jun 30, 2019·Oxidative Medicine and Cellular Longevity·Svetlana SoodaevaIldar Batyrshin
Oct 8, 2017·BMC Neuroscience·Shikha PrasadLuca Cucullo
Sep 5, 2019·Mediators of Inflammation·Carresse L GeraldLeonard L Williams
Jul 21, 2017·American Journal of Respiratory and Critical Care Medicine·Norbert F Voelkel
Jun 23, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Chen Xingyuan, Qiu Chen

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