Exhaled Nitric Oxide and Airway Hyperresponsiveness to Adenosine 5'-monophosphate and Methacholine in Children with Asthma

International Archives of Allergy and Immunology
Matthew S Perzanowski, Young Yoo

Abstract

There is increasing interest in the role of indirect bronchial challenges because clinical studies have shown that indirect airway hyperresponsiveness (AHR) reflects underlying airway inflammation better than direct AHR. Fractional exhaled nitric oxide (FeNO) appears to be a useful clinical tool for assessing airway inflammation noninvasively. We examined whether FeNO is more closely related to AHR to indirect stimuli than AHR to direct stimuli in children with mild to moderate asthma. Fifty-nine asthmatic children aged 6-16 years without rhinitis, underwent spirometry, FeNO measurement and blood tests for serum total IgE, blood eosinophil count and serum eosinophil cationic protein (ECP). All subjects underwent methacholine and adenosine 5-monophosphate (AMP) challenge tests at intervals of 3 days. In a univariate linear regression analysis, FeNO was significantly associated with both PC20 AMP (R(2) = 0.341, p < 0.001) and PC20 methacholine (R(2) = 0.188, p = 0.001). After adjustment for age, sex, serum total IgE and blood eosinophil count, the association between FeNO and PC20 AMP (β = -1.98, p = 0.001) was more robust than that between FeNO and PC20 methacholine (β = -0.87, p = 0.081). The significant correlation between FeN...Continue Reading

Citations

Mar 3, 2017·International Archives of Allergy and Immunology·Giorgio CiprandiIgnazio Cirillo
Jan 6, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Young A ParkMyung Hyun Sohn
Aug 18, 2017·European Clinical Respiratory Journal·Silvia Sánchez-GarcíaSantiago Quirce
Oct 27, 2018·The European Respiratory Journal·Teal S HallstrandUNKNOWN American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force

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