Exhaled nitric oxide in asthma: variability, relation to asthma severity, and peripheral blood lymphocyte cytokine expression

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Goutam P ShomeSharma Prabhakar

Abstract

Exhaled nitric oxide has been used as a means of indirectly measuring the underlying inflammation in asthma. The objectives of the study were to measure exhaled nitric oxide levels in asthma patients and healthy volunteers, to study peripheral blood lymphocyte cytokine expression, and to study the relationship between exhaled nitric oxide and intracellular cytokine expression. Exhaled nitric oxide was elevated in patients with moderate to severe asthma and with treatment decreased in the first week reaching to a near normal level by 4 weeks. Elevated exhaled nitric oxide was associated with decreased IL-4 and IL-13 cytokine expression by CD8 lymphocytes.

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Citations

Jun 13, 2008·Pulmonary Pharmacology & Therapeutics·Guglielmo de LaurentiisMatteo Sofia
Feb 19, 2010·European Journal of Applied Physiology·Sara K RosenkranzCraig A Harms
Feb 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rafael MarinoDanuta Radzioch
Jan 1, 2021·Journal of Asthma and Allergy·Yuki AbeSatoshi Konno

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