Exhaled nitric oxide levels during treatment in patients hospitalized with asthma

Allergy and Asthma Proceedings
Alan P BaptistM Safwan Badr

Abstract

The time required for fractional excretion of nitric oxide (FE(NO)) measurements to acutely change after systemic corticosteroids is unknown, limiting the usefulness of this biomarker in hospital treatment and discharge decisions. The purpose of this study was to follow FE(NO) measurements of hospitalized adult patients with asthma receiving therapy and to correlate FE(NO) with forced expiratory volume in 1 second percent predicted (FEV(1)%). Ten acute asthmatic patients who required hospitalization were recruited and treated with standard therapy. FE(NO) measurements were performed at presentation to the emergency department (baseline), as well as 1, 4, 6, 8, 12, and 24 hours after the initiation of therapy. FEV(1)% was measured at baseline, 1, 6, 12, and 24 hours. Subjects also were called 3 days after discharge to assess if symptoms had improved. The baseline FE(NO) was 57.5 parts per billion (ppb). There was no significant change over the first 8 hours. At 12 hours, there was an increase to 96.5 ppb (p = 0.01). Compared with baseline, all 10 subjects showed an increase at the 12-hour time point, with an average increase of 52%. The correlation between change in FE(NO) and change in FEV(1)% approached significance (p = 0.089...Continue Reading

Citations

Dec 17, 2008·Current Opinion in Pulmonary Medicine·Anandhi MuruganWilliam J Calhoun
Jul 31, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jason S DebleyEdward R Carter
Dec 9, 2008·Emergency Medicine Clinics of North America·Ani AydinAdam J Singer
Sep 4, 2013·Pediatric Pulmonology·Chee Chun TanCarolyn M Kercsmar
Oct 27, 2009·The American Journal of Medicine·Jerry A KrishnanBrian H Rowe
Mar 24, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ozlem KeskinOmer Kalayci

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